Dental Implants with Bone Grafts for Toothless Patients
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests new types of bone grafts for individuals receiving dental implants, especially those missing teeth. The goal is to determine if these new dentin grafts, made from tooth material, perform as well as or better than standard cadaver-derived bone grafts. Researchers will divide participants into groups to receive either the new grafts or the standard ones. Ideal participants are adults missing teeth with well-controlled health conditions. As an unphased trial, this study allows participants to contribute to innovative dental research that could enhance future treatment options.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but if you are using bisphosphonates, you cannot participate.
What prior data suggests that these dental implant and bone graft techniques are safe for toothless patients?
Research shows that using one's own tooth material for grafts, such as the partially demineralized and mineralized dentin grafts under study, is generally safe in dentistry. One study with 16 patients using partially demineralized dentin for dental implants reported no complications, either in the body or at the implant site, indicating the treatment was well-tolerated.
For mineralized tooth grafts, studies also show they are safe. Over time, these grafts have successfully integrated into the jawbone with minimal bone loss. Comparisons with other treatments have found them equally effective and safe.
Overall, current evidence suggests that both types of dentin grafts have been used safely in previous studies, with no major side effects reported. However, individual experiences can vary, so discussing any concerns with a healthcare provider is important.12345Why are researchers excited about this trial's treatments?
Researchers are excited about these dental graft treatments because they offer innovative approaches for patients needing dental implants. Unlike traditional options such as synthetic bone grafts, these treatments use mineralized and demineralized dentin grafts derived from the patient's own teeth. This method could potentially enhance compatibility and reduce the risk of rejection. Additionally, using partially-demineralized tooth grafts might promote better integration with the jawbone, leading to more successful and stable implant placements. Overall, these treatments represent a promising step forward in dental implant technology by leveraging natural materials for improved outcomes.
What evidence suggests that this trial's treatments could be effective for toothless patients?
Research has shown that partially-demineralized tooth grafts, one of the treatment options in this trial, can effectively preserve bone for dental implants. These grafts help maintain or improve bone levels, similar to other common graft materials. One study found they are a good option for preserving the bone that holds teeth in place.
For mineralized tooth grafts, another treatment option in this trial, studies have highlighted their potential to help regrow bone for implant placement. Specifically, research found these grafts led to about 44% new bone growth. They performed well compared to other materials, showing promising results for dental implants.
This trial studies both types of grafts as alternatives to traditional methods, aiming to provide effective results with fewer complications.678910Who Is on the Research Team?
Robin Henderson, DDS, MS
Principal Investigator
University of Oklahoma
Are You a Good Fit for This Trial?
This trial is for adults aged 18 to 80 with well-controlled health conditions, who need dental implants and can consent to study requirements. It's not for those with recent head/neck radiation, active gum disease, uncontrolled health issues, heavy smokers, bisphosphonate users, or pregnant/lactating women.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Surgical Intervention
Surgical intervention for implant placement for all groups
Follow-up
Participants are monitored for implant stability and bone level changes
Restoration
Restoration of the implant by the restorative dentist
What Are the Treatments Tested in This Trial?
Interventions
- Autogenous Mineralized and Demineralized Dentin Grafts
- Dental Implant Placement
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Oklahoma
Lead Sponsor
Zimmer Biomet
Industry Sponsor
Dr. Nitin Goyal
Zimmer Biomet
Chief Medical Officer since 2021
MD from Harvard Medical School
Ivan Tornos
Zimmer Biomet
Chief Executive Officer since 2023
MBA from the University of Miami School of Business, BBA in Finance and International Marketing and Management from the University of Georgia Terry College of Business