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Bone Graft

Dental Implants with Bone Grafts for Toothless Patients

N/A
Waitlist Available
Led By Robin Henderson, DDS, MS
Research Sponsored by University of Oklahoma
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Must not have
Current use of bisphosphonates or history of IV bisphosphonate therapy.
Presence of active periodontal disease.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing new tooth-based bone grafts against standard human bone grafts in patients needing bone grafts for dental implants. The grafts help new bone grow to support the implants by acting like a scaffold.

Who is the study for?
This trial is for adults aged 18 to 80 with well-controlled health conditions, who need dental implants and can consent to study requirements. It's not for those with recent head/neck radiation, active gum disease, uncontrolled health issues, heavy smokers, bisphosphonate users, or pregnant/lactating women.
What is being tested?
The trial tests if mineralized or partially demineralized dentin grafts used in dental implant placement are as effective as the standard cadaver bone graft (FDBA) in terms of implant stability and success rates without requiring a second surgical site.
What are the potential side effects?
While specific side effects aren't listed for this procedure, typical risks may include infection at the surgery site, inflammation or pain around the implant area, and potential rejection of the graft material.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I am currently using or have used bisphosphonates.
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I have active gum disease.
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I have had radiotherapy on my head or neck in the last 5 years.
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I do not have any uncontrolled illnesses.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Implant Failure Rate
Implant Stability as Measured with ISQ values of implant
Interproximal crestal bone level
+1 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups
Experimental Treatment
Group I: mineralized tooth graftExperimental Treatment1 Intervention
edentulous site grafted with mineralized tooth graft in the previous study.
Group II: Partially-demineralized tooth graftExperimental Treatment1 Intervention
edentulous site grafted with partially-demineralized tooth graft in the previous study.
Group III: Freeze-Dried Bone AllograftExperimental Treatment1 Intervention
edentulous site grafted with FDBA in previous study.

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.
Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
Common treatments for Toothless Alveolar Ridge include the use of bone graft materials such as autografts, allografts, xenografts, and alloplastic grafts. These treatments work primarily through osteoinduction and osteoconduction. Osteoinduction involves the stimulation of progenitor cells to develop into osteoblasts, which are essential for new bone formation. Osteoconduction provides a scaffold that supports the growth of new bone by allowing the migration of osteogenic cells. These mechanisms are crucial for patients with Toothless Alveolar Ridge as they promote the regeneration of bone, ensuring better stability and support for dental implants, ultimately improving oral function and aesthetics.
Effects of the bilayer nano-hydroxyapatite/mineralized collagen-guided bone regeneration membrane on site preservation in dogs.

Find a Location

Who is running the clinical trial?

Zimmer BiometIndustry Sponsor
377 Previous Clinical Trials
67,965 Total Patients Enrolled
University of OklahomaLead Sponsor
473 Previous Clinical Trials
93,621 Total Patients Enrolled
Robin Henderson, DDS, MSPrincipal InvestigatorUniversity of Oklahoma

Media Library

Autogenous Mineralized and Demineralized Dentin Grafts (Bone Graft) Clinical Trial Eligibility Overview. Trial Name: NCT05219305 — N/A
Toothless Alveolar Ridge Research Study Groups: Freeze-Dried Bone Allograft, Partially-demineralized tooth graft, mineralized tooth graft
Toothless Alveolar Ridge Clinical Trial 2023: Autogenous Mineralized and Demineralized Dentin Grafts Highlights & Side Effects. Trial Name: NCT05219305 — N/A
Autogenous Mineralized and Demineralized Dentin Grafts (Bone Graft) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05219305 — N/A
Toothless Alveolar Ridge Patient Testimony for trial: Trial Name: NCT05219305 — N/A
~16 spots leftby Dec 2025