Your session is about to expire
← Back to Search
Light + Negative Ion Therapy for Depression
N/A
Recruiting
Led By Raymond W Lam, MD
Research Sponsored by University of British Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
In remission as defined by score ≤10 on the clinician-rated Montgomery-Asberg Depression Rating Scale (MADRS) at both the screening visit and baseline visit, at least 2 weeks apart.
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 36 months
Awards & highlights
Study Summary
This trialwill test if light & negative ion therapy can replace antidepressants to help those in remission from depression stay well, w/o relapse. 100 people will be monitored for 28 weeks as they stop their antidepressants to see if the therapies work.
Who is the study for?
This trial is for adults with recurrent major depressive disorder (MDD) who are in remission thanks to antidepressants and want to stop their medication due to side effects or other reasons. They must meet specific criteria, have been on a stable dose of antidepressants, and be willing to do self-reports in English or French. People with significant personality disorders, high suicide risk, recent substance abuse, severe medical conditions, history of bad reactions when stopping antidepressants, eye conditions that limit light therapy use, or those using certain medications can't join.Check my eligibility
What is being tested?
The LIMIT-D study is exploring if negative ion therapy and light therapy can help prevent depression from coming back after stopping antidepressants. It's a preliminary test involving 100 participants over 28 weeks where half will receive active treatments and the other half inactive ones as they gradually stop taking their medication.See study design
What are the potential side effects?
While not explicitly listed for this feasibility study, potential side effects may include eye strain or discomfort from light therapy and irritation or dryness from negative ion therapy. Since it's testing non-medication treatments as substitutes for antidepressants during withdrawal periods, typical drug-related side effects might be avoided.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am in remission from depression, with low scores on a depression scale.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 36 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~36 months
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Recruitment rate
Secondary outcome measures
Adherence to study treatment
All-cause dropout rate
Rate of stopping antidepressants
Other outcome measures
Adverse events
Relapse rate
Serious adverse events
+1 moreTrial Design
2Treatment groups
Active Control
Group I: Negative ion therapyActive Control1 Intervention
High density negative ions at 3.4 trillion ions per second with no detectable ozone, used for 30 minutes as soon as possible after awakening, preferably between 7:00-8:00 am.
Group II: Light therapyActive Control1 Intervention
4000 Kelvin white fluorescent light rated at 10,000 lux at 14 inches from screen to cornea, with an ultraviolet filter, used for 30 minutes as soon as possible after awakening, preferably between 7:00-8:00 am.
Find a Location
Who is running the clinical trial?
Ontario Brain InstituteOTHER
11 Previous Clinical Trials
2,929 Total Patients Enrolled
Centre for Addiction and Mental HealthOTHER
356 Previous Clinical Trials
81,344 Total Patients Enrolled
University of British ColumbiaLead Sponsor
1,418 Previous Clinical Trials
2,467,018 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I want to stop my antidepressant due to side effects or other reasons.I am continuing with my current depression treatment.My main mental health condition is major depressive disorder, not bipolar disorder.I use medication for mental health that isn't an antidepressant or benzodiazepine.I am in remission from depression, with low scores on a depression scale.I can complete surveys and online tasks in English or French.I have started or plan to start therapy like CBT within 3 months.I do not have any major neurological disorders or recent severe head injuries.I haven't taken any photosensitizing medication in the last week.I have an eye condition that prevents me from undergoing bright light treatment.I have had severe reactions when stopping antidepressants.I have been on the same antidepressant dose for the last month.You have a high risk of suicidal thoughts or actions, as determined by a doctor.You have had a significant problem with alcohol or drug abuse in the past 6 months.I have been diagnosed with depression that changes with seasons or includes psychosis.
Research Study Groups:
This trial has the following groups:- Group 1: Negative ion therapy
- Group 2: Light therapy
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is my profile compatible with the requirements of this medical experiment?
"Hundred individuals between the ages of 19 and 65 with unipolar depression that adhere to DSM-5 criteria for Major Depressive Disorder, have had two or more episodes as determined by MINI, are on approved doses of antidepressants for 3-12 months (with no changes in dosage within last month), are in remission based on their score ≤10 MADRS at both screening visit & baseline visit (2 weeks apart) and can understand English/French sufficiently enough to complete online assessments will be admitted into this trial."
Answered by AI
Is there still availability for those wishing to participate in this experiment?
"According to clinicaltrials.gov, this investigation was initially posted in early December 2022 and recently updated on the 18th of November 2022. The research is currently accepting volunteers for its study."
Answered by AI
Are individuals of younger ages admissible for this trial?
"As established by the trial's eligibility criteria, potential participants must be aged between 19 and 65."
Answered by AI
How many participants are accepted into this medical experiment?
"Affirmative. According to clinicaltrials.gov, the trial in question is currently recruiting participants; it was first posted on December 1st 2022 and has been recently updated on November 18th 2022 with a goal of enrolling 100 patients at one centre."
Answered by AI
Recent research and studies
Other Trials to Consider
Popular Categories
Share this study with friends
Copy Link
Messenger