Sample Collection for Cancer

Recruiting at 86 trial locations

Age: Any Age

Sex: Any

Trial Phase: Academic

Sponsor: National Cancer Institute LAO

Must not be taking: Antibiotics, Antifungals, Antivirals

Disqualifiers: Invasive infections, HIV, Hepatitis, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

5000 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to collect and store tissue and blood samples from cancer patients. The main goal is to use these samples in the lab to better understand cancer and test new drugs. Patients currently undergoing cancer treatment or those diagnosed but not yet treated might be suitable candidates. This includes individuals with a new or ongoing cancer diagnosis, particularly if the cancer is progressing or stable. The trial involves a cytology specimen collection procedure, a method used to collect cells from tissues for examination. As an unphased trial, this study offers patients the opportunity to contribute to groundbreaking research that could lead to new cancer treatments.

Do I have to stop taking my current medications for this trial?

The trial protocol does not specify if you need to stop taking your current medications. However, it mentions that specimen collection should occur as far from the most recent drug administration as possible, suggesting that timing around your treatment cycles is important.

Why are researchers excited about this trial?

Researchers are excited about this trial because it focuses on the collection and storage of tissue and blood samples from cancer patients, which could pave the way for future breakthroughs. Unlike current treatments that directly target cancer cells, this approach involves preserving samples for later analysis. This enables scientists to use advanced xenograft models and in vitro cell cultures to study cancer more effectively. By understanding the biology of tumors better, researchers hope to develop more precise and personalized treatment options down the road.

Who Is on the Research Team?

James H Doroshow

Principal Investigator

National Cancer Institute (NCI)

Are You a Good Fit for This Trial?

Inclusion Criteria

Patients 18 year of age or older who are being evaluated, treated or enrolled in a clinical trial for cancer at participating sites

Patients with a histologically or cytologically confirmed diagnosis of cancer

Patients without histologically or cytologically confirmed diagnosis of cancer, but for whom approval has been requested and received from the coordinating site study coordinator Radiographic imaging (computed tomography [CT], magnetic resonance imaging [MRI], etc.)

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Sample Collection

Tumor tissue and blood samples are procured during procedures required for clinical management

Ongoing as per clinical procedures

Storage and Model Generation

Samples are stored via xenograft models or in vitro cell culture for future analysis

Up to 5 years

Follow-up

Participants are monitored for safety and effectiveness after sample collection

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Cytology Specimen Collection Procedure

How Is the Trial Designed?

Group I: Observational (tissue and blood procurement) Experimental Treatment 1 Intervention

Tumor tissue and blood samples are procured during procedures that are required for the patients' clinical management and stored via xenograft (transplant to another species) models or in vitro cell culture for future analysis.

Who Is Running the Clinical Trial?

National Cancer Institute LAO

Lead Sponsor

Trials

2

Recruited

5,100+

National Cancer Institute (NCI)

Collaborator

Trials

14,080

Recruited

41,180,000+