Platelet Poor Plasma Injections for Lower Extremity Injuries
What You Need to Know Before You Apply
What is the purpose of this trial?
The investigators hypothesize that a single injection of platelet-poor plasma (PPP) into an acute muscle injury will significantly improve local muscle regeneration and patient outcomes compared to the standard of care using only ultrasound-guided hematoma aspiration. Muscle regeneration will be assessed through quantitative MRI analysis. The investigators anticipate that PPP injections will lead to a measurable reduction in scar tissue and an increase in regenerated muscle tissue at the injury site over a six-month period.
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a single injection of platelet-poor plasma (PPP) into the acute muscle injury site, followed by physical therapy
Follow-up
Participants are monitored for changes in scar tissue volume and muscle regeneration through MRI analysis
What Are the Treatments Tested in This Trial?
Interventions
- Platelet Poor Plasma (PPP) Injection
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
US-guided aspiration of hematoma (if present) and injection of small volume (1-6cc's) of autologous platelet poor plasma (PPP) at the site of injury and post-injection physical therapy.
Standard of care pathway with US-guided aspiration of hematoma (if present) and physical therapy only.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Colorado, Denver
Lead Sponsor
Emory University
Collaborator
University of Iowa
Collaborator
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