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Radiation Therapy

MRI-Guided Radiation Therapy for Cancer (JUMP Trial)

N/A

Recruiting

Led By Lisa Singer, MD

Research Sponsored by Dana-Farber Cancer Institute

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age: 18 years or older

Participants must have a confirmed malignancy requiring radiation therapy.

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1 year

Awards & highlights

JUMP Trial Summary

This trial will test whether using MRI to plan radiation treatment is more effective than the current standard.

Who is the study for?

This trial is for adults over 18 with certain cancers (like prostate, liver, and head & neck) who need radiation therapy. They should be relatively active (able to care for themselves), able to consent, and meet specific criteria listed in subprotocols. People can't join if they have allergies to MRI contrast agents or can't undergo an MRI.Check my eligibility

What is being tested?

The study is testing the use of MRI simulation alongside standard radiation therapy in treating cancer. It's a two-phase study aiming to see how well this combination works and how feasible it is as a treatment planning method.See study design

What are the potential side effects?

Potential side effects may include those typically associated with MRIs such as discomfort from lying still during the scan or reactions to contrast agents if used. Radiation therapy side effects might include skin changes, fatigue, and area-specific effects depending on the cancer location.

JUMP Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am 18 years old or older.

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My cancer needs radiation therapy.

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I can take care of myself but might not be able to do active work.

JUMP Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 year

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 year

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Feasibility of acquiring MRI simulation prior to radiation therapy planning

Proportion of patients with QOL decline exceeding 2 x MID

Secondary outcome measures

Change in coverage of target volumes between CT simulation and MRI simulation

Change in dose to organs at risk (OARs) between CT simulation and MRI simulation

Change in target volumes between CT simulation and MRI simulation

+5 more

JUMP Trial Design

3Treatment groups

Experimental Treatment

Group I: Phase II MR Simulation Protocol: Track BExperimental Treatment2 Interventions

Adjusted Margin or / Dose Painted RT Based on Imaging of MR Simulator (e.g. biological imaging or higher resolution imaging)

Group II: Phase II MR Simulation Protocol: Track AExperimental Treatment2 Interventions

MR-only Radiation Therapy Simulation MRI-simulation and synthetic CT to plan treatment

Group III: Phase I MRI SimulationExperimental Treatment2 Interventions

This research study involves a screening period to determine eligibility. - Radiation mapping to define the target for radiation.acquiring MR data at the specified timepoint in a patient's care plan and ability to identify the radiation target and develop a radiation therapy plan on the MR data.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Radiation Therapy

2017

Completed Phase 3

~7250

0 / 3Eligibility criteria met