Gene Therapy Follow-Up for Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial monitors the long-term health of individuals who previously received a vaccine known as poxviral vector gene transfer. These vaccines use a virus to deliver genetic material, aiding the body in fighting diseases like cancer. The trial does not involve new medications; it focuses on annual health check-ups to monitor for any delayed side effects. It is designed for those who received these vaccines through specific studies at the National Cancer Institute. Participants will undergo yearly health assessments for up to 15 years to ensure continued well-being. As an unphased trial, this study allows participants to contribute to valuable long-term health data without requiring new treatments.
Why are researchers excited about this trial?
Researchers are excited about poxviral vector gene transfer treatments because they offer a novel approach to delivering genetic material directly into cells to potentially correct genetic disorders at their source. Unlike traditional treatments that often manage symptoms, this technique uses a modified virus as a vehicle to introduce new or modified genes into the patient's cells. This method could provide a more targeted and potentially long-lasting solution, addressing the root cause of the condition rather than just alleviating its symptoms. Additionally, this approach may offer benefits in terms of safety and efficiency compared to other gene therapy methods, as poxviral vectors are designed to reduce immune responses and enhance gene delivery.
Who Is on the Research Team?
Jennifer L Marte
Principal Investigator
National Cancer Institute (NCI)
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Follow-up
Annual medical history and physical examinations for the first 5 years following the last vaccine
Extended Follow-up
Annual telephone contact during the last 10 years
Long-term Monitoring
Health status check including primary cancer status, secondary malignancies, neurologic disorders, autoimmune disorders, and hematologic disorders
What Are the Treatments Tested in This Trial?
Find a Clinic Near You
Who Is Running the Clinical Trial?
National Cancer Institute (NCI)
Lead Sponsor
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