Iron Supplement for Iron Deficiency
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a new iron supplement (FeSC) to determine its effects on iron levels, gut health, and exercise performance in female endurance athletes. It seeks cis-gendered females aged 14-18 with low iron levels who have been menstruating for at least a year and regularly engage in endurance activities like running or cycling for 3 or more hours a week. Participants should not have recently taken iron supplements, prebiotics, or probiotics. As an unphased trial, this study provides a unique opportunity to contribute to research that could enhance athletic performance and overall health.
Do I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you've taken iron supplements, prebiotics, or probiotics in the last 3 months.
Is there any evidence suggesting that this treatment is likely to be safe for humans?
Research has shown that the iron supplement FeSC is usually easy for people to take. In studies, most participants using FeSC experienced few side effects. These studies included active women, similar to those who might join this trial. While some individuals experienced mild stomach problems, this was uncommon. Overall, current research suggests that FeSC is safe.12345
Why are researchers excited about this trial?
Unlike current treatments for iron deficiency, which often rely on traditional iron salts like ferrous sulfate, the iron/yeast complex (FeSC) is unique because it combines iron with yeast to enhance absorption and reduce gastrointestinal side effects. Researchers are excited about FeSC because its innovative formulation could improve how the body absorbs iron, potentially offering a more effective and gentler alternative for people who struggle with traditional iron supplements. This approach could mean fewer stomach issues, like constipation or nausea, which are common complaints with standard iron pills.
What evidence suggests that this treatment might be an effective treatment for iron deficiency?
Research has shown that many female athletes often lack sufficient iron, leading to fatigue and decreased performance. Studies have found that iron in yeast, such as the FeSC supplement tested in this trial, might be absorbed better by the body than regular iron. Animal studies suggested it could be more effective in treating anemia. This supplement aims to boost iron levels, improve gut health, and enhance exercise performance in endurance athletes. Although research on humans is ongoing, these early results indicate it could be a promising method to improve athletic performance by addressing iron deficiency.13678
Who Is on the Research Team?
Jane Shearer, PhD
Principal Investigator
University of Calgary
Are You a Good Fit for This Trial?
This trial is for cis-gendered female athletes aged 14-18 with low iron levels (ferritin ≤45mcg/L) who are at least one year past menarche and do moderate to vigorous endurance activities for a minimum of three hours weekly.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants consume 40mg of elemental iron every second day for 8 weeks and complete weekly surveys on stress, recovery, and gastrointestinal symptoms.
Follow-up
Participants are monitored for safety and effectiveness after treatment, including assessments of iron status, gut microbiome, and exercise capacity.
What Are the Treatments Tested in This Trial?
Interventions
- FeSC
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Calgary
Lead Sponsor
Natural Sciences and Engineering Research Council, Canada
Collaborator
Mitacs
Industry Sponsor