Blueberry Supplementation for Immune Response Enhancement
(Blueberry Trial)
Trial Summary
What is the purpose of this trial?
This research study will test the effects of almonds on immune functions and immune response to influenza vaccine in overweight older men and postmenopausal women
Will I have to stop taking my current medications?
The trial requires that you are not taking any medications or supplements that affect immunity. If your current medications do affect immunity, you may need to stop taking them to participate.
What data supports the effectiveness of the treatment Blueberry powder for immune response enhancement?
Is blueberry supplementation safe for humans?
How does blueberry powder treatment enhance immune response compared to other treatments?
Blueberry powder is unique because it contains flavonoids and polyphenolic compounds that have antioxidant and anti-inflammatory properties, which may enhance immune response by reducing inflammation and oxidative stress. Unlike standard treatments, it uses natural ingredients and is consumed as a dietary supplement, making it a novel approach to boosting immunity.167911
Research Team
Joan Sabate, DrPH
Principal Investigator
Loma Linda University
Sujatha Rajaram, PhD
Principal Investigator
Loma Linda University
Eligibility Criteria
This trial is for overweight older men and postmenopausal women aged 50-70 who agree to get a flu shot. They must have a BMI of 25-32, be able to travel to Loma Linda University, and not be on immune-affecting meds or supplements. Those regularly eating berries, on immune boosters, recently on antibiotics or steroids, allergic to blueberries, vaccinated for flu within the last 10 months, or with uncontrolled diseases can't join.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Phase 1 - Blueberry Consumption
Participants consume blueberries or placebo powder to examine effects on plasma markers of immune strength
Phase 2 - Vaccination and Continued Consumption
Participants receive influenza vaccination and continue blueberry or placebo consumption to assess immune response
Follow-up
Participants are monitored for changes in immune response and viral load after the intervention
Treatment Details
Interventions
- Blueberry powder group
- Placebo powder group
Find a Clinic Near You
Who Is Running the Clinical Trial?
Loma Linda University
Lead Sponsor
U.S. Highbush Blueberry Council
Collaborator