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Exercise for Sleep and Inflammation in HIV (REST Trial)

N/A

Recruiting

Research Sponsored by Christine Horvat Davey

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Confirmed HIV infection

On a current, modern antiretroviral therapy (ART) (anti-retroviral regimen)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 0-8 weeks and 0-16 weeks

Awards & highlights

REST Trial Summary

This trial will compare the effects of two types of exercise on sleep and inflammation in older people with HIV.

Who is the study for?

This trial is for people over 50 living with HIV who have poor sleep quality, are on modern antiretroviral therapy, and lead a sedentary lifestyle. They must not have uncontrolled high blood pressure, serious heart conditions without clearance, or severe pulmonary disease requiring oxygen.Check my eligibility

What is being tested?

The study tests how two types of exercise—high-intensity interval training (HIIT) and continuous moderate-intensity exercise (CME)—affect sleep and inflammation in older adults with HIV. Participants will be randomly assigned to one of the exercise programs for 16 weeks.See study design

What are the potential side effects?

While specific side effects aren't listed for HIIT or CME, general risks may include muscle soreness, fatigue, increased heart rate during exercise, and potential exacerbation of existing health issues.

REST Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am HIV positive.

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I am on a modern HIV treatment regimen.

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I have poor sleep quality according to the Pittsburgh Sleep Quality Index.

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I am 50 years old or older.

REST Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 0-8 weeks and 0-16 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~0-8 weeks and 0-16 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 0-8 weeks and 0-16 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Interleukin inflammation markers

Mean sleep duration

Sleep efficiency

+2 more

Secondary outcome measures

C-reactive protein inflammation marker

Interferon gamma inflammation marker

Inflammation

REST Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: High intensity interval trainingExperimental Treatment1 Intervention

Group II: Continuous moderate intensity exerciseActive Control1 Intervention

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

HIIT

2011

N/A

~730

0 / 4Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of WashingtonOTHER

1,740 Previous Clinical Trials

1,847,888 Total Patients Enrolled

University of Colorado, DenverOTHER

1,734 Previous Clinical Trials

2,148,833 Total Patients Enrolled

Christine Horvat DaveyLead Sponsor

Media Library

CME Clinical Trial Eligibility Overview. Trial Name: NCT04946994 — N/A

HIV (Human Immunodeficiency Virus) Research Study Groups: High intensity interval training, Continuous moderate intensity exercise

HIV (Human Immunodeficiency Virus) Clinical Trial 2023: CME Highlights & Side Effects. Trial Name: NCT04946994 — N/A

CME 2023 Treatment Timeline for Medical Study. Trial Name: NCT04946994 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is enrollment currently open to participants in this research?

"As evidenced by the details on clinicaltrials.gov, this experiment is seeking volunteers; it was first posted in October of 2021 and recently revisited during February 2022."

Answered by AI

How many patients are being recruited into this research program?

"Affirmative. According to data on clinicaltrials.gov, this medical investigation is actively attempting to find participants, having been initially posted in October of 2021 and edited as recently as February 10th 2022. The study requires 50 individuals at 2 sites for completion."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Relationship of Exercise, Sleep, and Inflammation Markers in People Living With HIV

Christine Horvat Davey 2021. "Relationship of Exercise, Sleep, and Inflammation Markers in People Living With HIV". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04946994.