← Back to Search

Exercise for Enhancing COVID-19 Immunization

N/A

Recruiting

Research Sponsored by Iowa State University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Planning to receive an initial mRNA Severe Acute Respiratory Distress Syndrome Coronavirus 2 vaccine

Between 18-64 years of age

Timeline

Screening 3 weeks

Treatment Varies

Follow Up serum samples collected pre-immunization, if intervention after initial vaccine, two weeks post initial dose, and approximately one month post-immunization.

Awards & highlights

Study Summary

This trial is investigating whether a single session of exercise shortly after receiving the third dose of the COVID-19 vaccine may improve the immune response to vaccination, and identify potential mechanisms behind this using gene expression and metabolite analysis.

Who is the study for?

This trial is for adults aged 18-70 who are planning to get their initial or booster dose of a COVID-19 mRNA vaccine, exercise regularly, and can safely do 90 minutes of light to moderate exercise. It's not for pregnant individuals, those on immune-altering meds (for the initial vaccine part), or with conditions that make exercising unsafe.Check my eligibility

What is being tested?

The study tests if doing light to moderate exercise right after getting a COVID-19 mRNA vaccine affects the body's immune response. Participants will either walk or jog under supervision after vaccination and have blood samples taken over time to measure immunity changes.See study design

What are the potential side effects?

While the side effects aren't specified for the exercise intervention itself, typical post-vaccination side effects like sore arm, fatigue, headache might be monitored especially since they're being measured for three days following vaccination.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I plan to get my first mRNA COVID-19 vaccine.

Select...

I am between 18 and 64 years old.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ time frame if intervention after initial covid immunization, approximately one and six months post-immunization.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~time frame if intervention after initial covid immunization, approximately one and six months post-immunization.

This trial's timeline: 3 weeks for screening, Varies for treatment, and time frame if intervention after initial covid immunization, approximately one and six months post-immunization. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Body Weight Changes

Change in Metabolites

Change in Serum antibody

+1 more

Secondary outcome measures

Potential role of psychosocial factors and change in immune response

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Exercise post-immunizationExperimental Treatment1 Intervention

After the initial mRNA-based COVID-19 vaccine is received, a supervised 90 minute light to moderate exercise session will take place.

Group II: Daily routine as usual (control)Active Control1 Intervention

After the initial mRNA-based COVID-19 vaccine is received, participants will be asked to go about their daily routine as usual, but avoid exercise for that day.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Exercise

2016

Completed Phase 1

~760

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

Iowa State UniversityLead Sponsor

59 Previous Clinical Trials

144,473 Total Patients Enrolled

Media Library

Exercise Clinical Trial Eligibility Overview. Trial Name: NCT05213000 — N/A

Immunizations Research Study Groups: Exercise post-immunization, Daily routine as usual (control)

Immunizations Clinical Trial 2023: Exercise Highlights & Side Effects. Trial Name: NCT05213000 — N/A

Exercise 2023 Treatment Timeline for Medical Study. Trial Name: NCT05213000 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the current research initiative open to elderly individuals?

"As outlined in the study's terms of admission, individuals who are 18 years old and above but below 70 can be considered for enrolment."

Answered by AI

Are there any opportunities to partake in this experiment currently?

"Clinicaltrials.gov currently displays that this medical trial is proactively recruiting participants, with the first post being dated October 15th 2021 and last updated on January 24th 2022."

Answered by AI

What are the prerequisites for joining this clinical experiment?

"This medical trial is recruiting 130 individuals with immunizations who are aged between 18 and 70. Further, suitable candidates must be willing to donate blood samples, intend to receive an mRNA-based Severe Acute Respiratory Distress Syndrome Coronavirus 2 vaccine booster dose, partake in physical activity regularly (e.g., walking/jogging for 90 minutes per American College of Sports Medicine guidelines), and demonstrate that they can perform light-to-moderate intensity exercises safely."

Answered by AI

How many participants have been selected to join this research endeavor?

"Indeed, the information on clinicaltrials.gov confirms that this research is actively recruiting participants. The trial was originally posted to the website in October of 2021 and last modified in January 2022; it seeks 130 people from a single site."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Adjuvant Effect of Physical Exercise on Immune Response to COVID-19 Vaccination and Interactions With Stress

Marian Kohut 2021. "Adjuvant Effect of Physical Exercise on Immune Response to COVID-19 Vaccination and Interactions With Stress". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05213000.