Watermelon for High Blood Pressure
(WMBP Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how eating watermelon might help manage high blood pressure (hypertension) in individuals with pre-hypertension. Researchers aim to determine if varying amounts of watermelon can influence blood pressure and other heart health markers, such as cholesterol and blood sugar levels. Participants will be divided into groups; some will consume different doses of watermelon flesh, while others will receive a calorie-matched drink without watermelon. Ideal candidates for this trial are non-smokers with high-normal blood pressure and no history of major diseases, who are not taking certain medications or supplements. As an unphased trial, this study provides a unique opportunity to understand how natural foods like watermelon can impact heart health.
Will I have to stop taking my current medications?
Yes, you will need to stop taking certain medications, such as cholesterol-lowering medications, anticoagulants, and blood pressure-lowering medications, as well as any prescription medications that might interfere with the study.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research shows that watermelon is generally safe for most people. Eating watermelon can help lower blood pressure and improve heart health. For example, one study found that eating fresh watermelon daily reduced blood pressure and improved cholesterol levels. A review from 2023 noted that some studies have shown watermelon can help lower blood pressure.
Watermelon contains nutrients like lycopene and citrulline, which are believed to benefit health. These nutrients may improve blood flow in the body. Most participants in studies experienced no problems eating watermelon, with few side effects reported. This suggests that eating watermelon is likely safe for many people, though individual experiences may vary. Consulting a doctor before making significant dietary changes is always advisable, especially for those with health conditions.12345Why are researchers excited about this trial?
Researchers are excited about using watermelon flesh to tackle high blood pressure because it's a natural, food-based approach. Unlike standard medications like ACE inhibitors or beta-blockers, which often come with side effects, watermelon offers a more gentle option. The magic lies in its high levels of citrulline, an amino acid that can help relax blood vessels and improve circulation. Plus, it's as simple as eating a cup or two of watermelon a day, making it an easy addition to anyone's diet.
What evidence suggests that watermelon flesh might be an effective treatment for high blood pressure?
Research shows that watermelon might help lower blood pressure. In one study, eating watermelon significantly reduced the systolic blood pressure by about 10.55 mmHg and the diastolic by 5.22 mmHg. Another study found that watermelon lowered both numbers in adults with high blood pressure. This trial will test the effects of different doses of watermelon flesh on blood pressure. Participants will receive either a control beverage or one of two doses of watermelon flesh. This effect likely occurs because watermelon contains L-citrulline, which can improve heart health by widening blood vessels. Overall, current evidence suggests that watermelon could effectively lower blood pressure in people with slightly elevated levels.16789
Who Is on the Research Team?
Indika Edirisinghe, Ph.D.
Principal Investigator
Illinois Institute of Technology
Are You a Good Fit for This Trial?
This trial is for healthy overweight/obese adults aged 25-65 with slightly elevated blood pressure but no history of serious health issues. Participants should be nonsmokers, not on a vegetarian diet, and have stable weight without plans to lose more. They shouldn't consume certain supplements or medications that affect blood pressure or metabolism.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Pre-Screening
Potential subjects complete a pre-screening questionnaire to assess eligibility
Screening
Participants are screened for eligibility to participate in the trial
Pre-Study Visit
Participants receive training and diet counseling, and are randomized into study groups
Treatment
Participants consume assigned test beverages daily for 4 weeks and attend study visits
Follow-up
Participants return ABPM machines and continue consuming treatment beverages
What Are the Treatments Tested in This Trial?
Interventions
- Watermelon Flesh
Find a Clinic Near You
Who Is Running the Clinical Trial?
Clinical Nutrition Research Center, Illinois Institute of Technology
Lead Sponsor
National Watermelon Promotion Board
Collaborator