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Electrolyte Transporter Blocker

Salt Resistant Adults for Salt Sensitivity of Blood Pressure

N/A

Recruiting

Research Sponsored by University of Delaware

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1 hour

Awards & highlights

Study Summary

This trial aims to understand how the brain senses salt and its effect on blood pressure. The researchers will use MRI to study how the brain reacts to increased salt levels in the blood by infusing a saline

Who is the study for?

This trial is for adults aged between 40 and 60 with normal potassium levels, no history of heart, kidney, metabolic or brain diseases. Participants should have slightly elevated blood pressure but not full hypertension, and a BMI indicating they are neither underweight nor obese.Check my eligibility

What is being tested?

The study tests how the brain reacts to high salt levels in the blood using MRI scans during saline solution infusions. It compares responses in people who are salt-sensitive (blood pressure changes with salt intake) versus those who aren't by monitoring their diet for seven days.See study design

What are the potential side effects?

Potential side effects may include discomfort from the infusion process, dehydration due to diuretic use which can cause increased urination, dizziness or lightheadedness especially if blood pressure drops too low.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 hour

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 hour

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 hour for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Bold fMRI

Secondary outcome measures

Blood Pressure

Other outcome measures

Sympathetic Nerve Activity

Trial Design

2Treatment groups

Experimental Treatment

Group I: Salt SensitiveExperimental Treatment2 Interventions

Adults who experience increased BP (mean arterial pressures >5mmHg) during dietary sodium challenge

Group II: Salt Resistant AdultsExperimental Treatment2 Interventions

Adults who experience minimal BP change during dietary sodium challenge

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

National Heart, Lung, and Blood Institute (NHLBI)NIH

3,840 Previous Clinical Trials

47,852,004 Total Patients Enrolled

University of DelawareLead Sponsor

154 Previous Clinical Trials

25,091 Total Patients Enrolled

1 Trials studying Salt Sensitivity of Blood Pressure

40 Patients Enrolled for Salt Sensitivity of Blood Pressure

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this clinical trial allow participation by individuals who are older than 85 years?

"To be considered for participation in this research study, individuals must fall between the ages of 40 and 60 years old."

Answered by AI

Are there any available positions for patients to participate in this clinical trial?

"Affirmative. Information from clinicaltrials.gov confirms that this medical trial is actively seeking participants. The trial was initially posted on March 5th, 2024 and last revised on March 13th, 2024. It aims to enroll a total of 120 individuals at one designated site."

Answered by AI

Which group of individuals is more suitable to be enrolled in this research study?

"Individuals aged between 40 and 60 exhibiting salt sensitivity in their blood pressure are eligible to participate in this trial, which aims to recruit a total of 120 participants."

Answered by AI

What is the current number of individuals receiving medical care as part of this clinical trial?

"Indeed, as indicated on clinicaltrials.gov, this particular investigation is actively seeking candidates. The study was first listed on March 5th, 2024 and the latest update occurred on March 13th, 2024. A total of 120 patients are sought from a single location."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study

2024. "Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06094816.