Apply to Trial

Compensation: Varies

Number of Visits: 13

Duration: 13 weeks

250 Participants Needed

Contact Lenses for Vision Correction

Overseen ByJose A Vega, OD,MSc,PhD

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: CooperVision International Limited (CVIL)

Must not be taking: Systemic medications

Disqualifiers: Anterior segment infection, Gas permeable lenses, others

No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests various contact lenses to evaluate their performance and comfort for wearers. Participants will try several types, including those with special features like blue light technology. It suits individuals who already wear soft contact lenses and have prescriptions ranging from -6.00 to +6.00. As an unphased trial, it allows participants to explore innovative contact lens technologies and contribute to advancements in eye care.

Will I have to stop taking my current medications?

The trial excludes people using medications that would interfere with wearing contact lenses, so you might need to stop certain medications. It's best to discuss your specific medications with the trial team.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research has shown that the contact lenses under study have varied safety profiles. The comfilcon A lens, approved for up to 7 days of continuous wear, is generally well-tolerated. The delefilcon A lens is known for comfort, with some studies noting long periods of comfortable wear. Fanfilcon A lenses have a few reported issues, such as eye redness, but these are uncommon.

Kalifilcon A lenses are safe and effective for daily wear. Lehfilcon A lenses have a low risk of side effects and retain moisture, enhancing comfort. Samfilcon A lenses are approved and widely used, demonstrating a strong safety record.

Senofilcon A lenses, available in bi-weekly and daily disposable options, offer UV protection and are known for their safety. Daily disposables have a lower risk of certain eye infections. The version with blue light technology provides additional protection against blue-violet light. Serafilcon A lenses are also safe for correcting vision problems like nearsightedness.

Somofilcon A lenses have some reports of irritation but are generally safe for daily use. Stenfilcon A lenses are mostly safe, though some reports of side effects exist. Lastly, the verofilcon A lens is noted for comfort and maintaining good vision, with few safety concerns reported in studies.

These lenses have been in use for some time, and while each has specific characteristics, they generally show a trend of being safe and well-tolerated.¹ ² ³ ⁴ ⁵

Why are researchers excited about this trial?

Researchers are excited about these contact lenses because they offer a variety of features aimed at improving vision correction. Unlike traditional lenses, some of these investigational lenses incorporate blue light technology, which could help reduce eye strain from digital screens. Moreover, with options ranging from daily disposables to bi-weekly replacements, these lenses provide flexibility and convenience for different user preferences. Each lens type is designed to maximize comfort and clarity, potentially setting a new standard for contact lens wearers.

What evidence suggests that this trial's contact lenses could be effective for vision correction?

This trial will evaluate thirteen types of contact lenses for vision correction. Research has shown that the comfilcon A lens fits well in 94.6% of cases, providing clear vision. Delefilcon A lenses are known for comfort, with 91% of users finding them more comfortable than expected. Studies indicate that fanfilcon A lenses offer excellent vision quality, even at night. Kalifilcon A lenses provide stable vision at various distances. Lehfilcon A lenses are praised for comfort and sharp vision. Samfilcon A lenses perform well in both comfort and vision compared to others. Senofilcon A lenses, with blue light technology, enhance vision outdoors and in changing light. Serafilcon A lenses effectively correct common vision issues like nearsightedness and farsightedness. Somofilcon A lenses are highly rated for both vision quality and comfort. Stenfilcon A lenses offer strong sharpness of vision, achieving clear sight for most users. Finally, verofilcon A lenses are highly rated for comfort and dryness, maintaining performance throughout the day. Participants in this trial will wear these lenses in a randomized order to assess their performance.⁶ ⁷ ⁸ ⁹ ¹⁰

Who Is on the Research Team?

Pete Kollbaum, OD, PhD

Principal Investigator

Indiana University

Are You a Good Fit for This Trial?

This trial is for individuals with vision issues like farsightedness or near-sightedness. Participants should be interested in trying out different types of contact lenses to assess their performance and comfort.

Inclusion Criteria

Refractive error of -6.00 to -0.50DS or +0.50 to +6.00DS and less than or equal to 0.75DC as vertexed to the corneal plane

Anisometropia no greater than 1.50D, based on vertexed manifest refraction spherical equivalent

Can achieve visual acuity of at least 20/25 in each eye with spherical equivalent manifest refraction

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Exclusion Criteria

Used gas permeable/hard contact lenses (including orthokeratology) in the previous 3 months

Participation in a contact lens or lens care product trial in the previous 30 days

I am not on any medication that prevents me from wearing contact lenses.

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Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants will wear thirteen different types of study contact lenses, in a randomized order of testing for the thirteen study contact lens types

13 weeks

13 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

comfilcon A lens
delefilcon A lens
fanfilcon A lens
kalilfilcon A lens
lehfilcon A lens
samfilcon A lens
senofilcon A bi-weekly lens
senofilcon A daily disposable lens
senofilcon A with blue light technology lens
serafilcon A lens
somofilcon A lens
stenfilcon A lens
verofilcon A lens

Trial Overview

The study is testing various contact lenses made from materials like stenfilcon A, fanfilcon A, and others. It aims to compare how these lenses perform in terms of vision correction and user acceptance over a set period.