Neurodevelopment for Huntington's Disease
(ChANGE HD Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how brain development might be affected in individuals with a genetic risk for Huntington's Disease (HD), a condition impacting thinking, emotions, and movement. Researchers aim to determine if brain changes occur long before any symptoms appear. Participants will undergo brain scans and various tests to assess brain structure and function. This trial is open to individuals aged 6 to 30 with a parent or grandparent with HD who are comfortable knowing their risk. Those with metal in their body or a history of major brain-related health issues are not eligible. As an unphased study, this trial offers a unique opportunity to contribute to understanding HD risk factors and potentially aid in early intervention strategies.
Why are researchers excited about this trial?
Researchers are excited about this trial because it explores the neurodevelopmental progression from childhood to adulthood in individuals with gene-expanded Huntington's disease. Unlike the standard treatments that mainly focus on managing symptoms in later stages, this study aims to understand early changes in the brain. By identifying these changes early on, scientists hope to uncover new intervention points and potentially develop more effective treatments targeting the root causes of the condition before significant symptoms appear. This approach could revolutionize how Huntington's disease is managed, shifting the focus from symptom control to prevention and early treatment.
Who Is on the Research Team?
Peggy C Nopoulos, MD
Principal Investigator
University of Iowa
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Initial assessment of brain structure and function using MRI, cognitive tests, and behavioral assessments
Annual Follow-up
Participants undergo annual assessments of brain structure and function, including MRI, cognitive tests, and behavioral assessments
Long-term Monitoring
Continued monitoring of brain development and function over several years
What Are the Treatments Tested in This Trial?
Find a Clinic Near You
Who Is Running the Clinical Trial?
Peggy C Nopoulos
Lead Sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborator