Brain Structure Assessment for Juvenile-onset Huntington's Disease
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to understand how brain development in young people with Juvenile-onset Huntington's Disease (JoHD) differs from those with the adult form of the disease. Researchers seek to identify specific brain changes that can serve as reliable markers for JoHD. Participants will undergo tests and scans to gather this information. Individuals diagnosed with JoHD, aged 6 to 30, and without other major health issues might be suitable for this study. As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research that may lead to better understanding and future treatments for JoHD.
Do I need to stop my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Why are researchers excited about this trial?
Researchers are excited about this trial because it's diving deep into understanding how juvenile-onset Huntington's disease affects the brain over time. Unlike existing treatments that primarily aim to manage symptoms, this observational study focuses on mapping changes in brain structure and function. By pinpointing these changes, scientists hope to uncover new insights that could lead to more effective interventions in the future. This approach is groundbreaking because it shifts the focus from symptom management to understanding the disease's progression at a fundamental level.
Who Is on the Research Team?
Peggy C Nopoulos, MD
Principal Investigator
University of Iowa
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Participants undergo initial cognitive tests, behavioral assessments, physical and neurologic evaluation, and MRI
Longitudinal Assessment
Participants are assessed for brain structure and function using MRI, cognitive tests, and behavioral assessments
Follow-up
Participants are monitored for changes in brain structure and function over time
What Are the Treatments Tested in This Trial?
Interventions
- Observational Study
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Iowa
Lead Sponsor
The University of Texas Health Science Center, Houston
Collaborator
Children's Hospital of Philadelphia
Collaborator
UCL Queen Square Institute of Neurology
Collaborator
George-Huntington-Institut GmbH
Collaborator
Columbia University
Collaborator
University of California, Davis
Collaborator
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