Resilience-Building Intervention for Aging Individuals with HIV

(RISE+ Trial)

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: University of Alabama at Birmingham

Disqualifiers: Neurological, Schizophrenia, Bipolar, Depression, others

Compensation: Varies

Number of Visits: 7

Duration: 4 weeks

100 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This study will examine the mechanisms and efficacy of a resilience building intervention in older people living with HIV.

Are You a Good Fit for This Trial?

This trial is for people over 50 with HIV who are patients at the UAB HIV Clinic. They should have had some trouble managing their HIV in the last year, like missing a clinic visit or having a detectable viral load. People with serious mental health conditions like schizophrenia, bipolar disorder, or major depression cannot join.

Inclusion Criteria

My HIV has not been well-managed in the past year, with missed appointments or detectable viral loads.

I am 50 years old or older.

Current UAB HIV Clinic patient

Exclusion Criteria

Severe psychiatric disorders (e.g., schizophrenia, bipolar disorder, major depression)

I have a neurological disorder.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Assessment

Participants complete a baseline assessment including a 14-day experience sampling method (ESM) protocol

2 weeks

1 visit (in-person)

Treatment

Participants attend four weekly two-hour group sessions, either in the RISE+ Resilience Intervention or Stress Reduction Control group

4 weeks

4 visits (in-person)

Post-Intervention Assessment

Participants complete a one-month post-intervention assessment including qualitative and quantitative feedback and a second ESM protocol

1 month

1 visit (in-person)

Follow-up

A three-month follow-up to assess health outcomes, including HIV treatment management abilities, health-related quality of life, depressive symptoms, HIV viral load, and medication adherence

3 months

1 visit (in-person)

What Are the Treatments Tested in This Trial?

Interventions

• RISE+
• Stress Reduction Control

Trial Overview The study is testing RISE+, an intervention designed to help build resilience and reduce stress in older adults living with HIV. It will be compared to a control group that receives standard stress reduction guidance.

How Is the Trial Designed?

Group I: RISE+ Resilience Intervention Experimental Treatment 1 Intervention

Participants in the intervention group will come to the lab for four two-hour weekly sessions in small groups of 3-4. The intervention includes psychoeducational videos and individual written activities on topics such as coping strategies, cognitive appraisals, the responsibility model, and social connections, all integrated into the overarching process of resilience. The intervention will be facilitated by a trained research assistant but as in the pilot study, he/she will be minimally involved (i.e., only administering the videos and explaining the activities) to keep the private reflective nature of the program that participants liked. Upon completion of the program, participants will be given handouts with summaries of the program material. We will gather qualitative and quantitative feedback on the intervention at the one-month posttest.

Group II: Stress Reduction Control Placebo Group 1 Intervention

Control participants will complete an attention-matched internet stress reduction paradigm, which includes an internet navigation protocol and placebo computer games. As with the intervention group, participants in the control group will come to the lab for four two-hour weekly sessions in small groups of 3-4. Facilitator involvement will be the same as the intervention group (e.g., the research assistant will explain computer activities and games but will otherwise not interact with the participant).

Who Is Running the Clinical Trial?

University of Alabama at Birmingham

Lead Sponsor

Trials

1,677

Recruited

2,458,000+

National Institute on Aging (NIA)

Collaborator

Trials

1,841

Recruited

28,150,000+