Wet-to-dry vs Petrolatum & Non-stick Dressings After Hidradenitis Suppurativa Surgery

Overseen By Franklin R Blum, BS

Age: Any Age

Sex: Any

Trial Phase: Academic

Sponsor: University of North Carolina, Chapel Hill

Disqualifiers: Surgically closed wounds, bandaging preference, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 1

Duration: 6 weeks

74 Participants Needed

Trial Summary

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It focuses on wound care after surgery for hidradenitis suppurativa.

What data supports the effectiveness of the treatment Petrolatum with Non-Stick Gauze, Wet-to-Dry Dressings?

Research suggests that wet-to-dry dressings are not optimal for wound healing compared to advanced dressings, which are more effective in reducing healing time, pain, and infection rates. However, petrolatum (a type of petroleum jelly) is often used in dressings to keep wounds moist, which can aid in healing. ^{1 2 3 4 5}

Is petrolatum safe for use in humans?

Petrolatum is commonly used as a moisturizer and in wound care, and it is generally considered safe for human use. However, some people may experience allergic reactions or skin irritation, especially when used with other drugs or in certain medical conditions. ^{1 6 7 8 9}

How does the treatment with Petrolatum and Non-Stick Gauze differ from other treatments for wound care?

This treatment uses petrolatum (a type of jelly) with non-stick gauze, which helps keep the wound moist and prevents the dressing from sticking to the wound, potentially reducing pain during dressing changes. Compared to other dressings, petrolatum dressings may allow better absorption of wound fluids and bacteria, which can be beneficial for healing. ^{1 6 10 11 12}

What is the purpose of this trial?

This trial compares two types of wound dressings for patients with a severe skin condition called Hidradenitis suppurativa. It aims to find out if petrolatum with non-stick bandaging is better than the traditional wet-to-dry method in terms of healing and comfort. The study will track healing progress and quality of life to determine the best approach.

Research Team

Christopher J Sayed, MD

Principal Investigator

University of North Carolina, Chapel Hill

Franklin R Blum, BS

Principal Investigator

University of North Carolina, Chapel Hill

Eligibility Criteria

Inclusion Criteria

Male & females > or = 16 years of age

Patient must be capable of performing either of the recommended wound care regimens on their own or have someone available to consistently assist with wound care.

Must be able to provide adequate informed consent for themselves

Exclusion Criteria

You cannot participate if you have a preference for a specific type of bandage.

Patients with surgically closed wounds (sutures, staples)

You have had trouble using wet-to-dry or petrolatum and non-stick bandages before.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive either wet-to-dry dressings or petrolatum with non-stick bandaging post-surgery

6 weeks

Visits at 1, 2, 4, and 6 weeks post-surgery

Follow-up

Participants are monitored for wound healing and quality of life outcomes

4 weeks

Treatment Details

Interventions

• Petrolatum with Non-Stick Gauze
• Wet-to-Dry Dressings

Participant Groups

Group I: Petrolatum with Non-Stick Gauze Experimental Treatment 1 Intervention

Participants in this arm will receive petrolatum with non-stick gauze.

Group II: Wet-to-dry Dressings Active Control 1 Intervention

Participants in this arm will receive standard of care wet-to-dry dressings.

Who Is Running the Clinical Trial?

University of North Carolina, Chapel Hill

Lead Sponsor

Trials

1,588

Recruited

4,364,000+

National Center for Advancing Translational Sciences (NCATS)

Collaborator

Trials

394

Recruited

404,000+

References

1. Scotland pubmed.ncbi.nlm.nih.gov

The use of semipermeable dressings in fingertip injuries. [2022]

2. United States pubmed.ncbi.nlm.nih.gov

Hanging wet-to-dry dressings out to dry. [2019]

3. United States pubmed.ncbi.nlm.nih.gov

Moist wound healing: the clinical perspective. [2022]

4. England pubmed.ncbi.nlm.nih.gov

Fluid handling performance of wound dressings tested in a robotic venous leg ulcer system under compression therapy. [2023]

5. United States pubmed.ncbi.nlm.nih.gov

Wet-to-Dry Dressings Do Not Provide Moist Wound Healing. [2020]

6. United States pubmed.ncbi.nlm.nih.gov

Effects of nonadherent dressing materials on the healing of open wounds in dogs. [2016]

7. United States pubmed.ncbi.nlm.nih.gov

Patch tests in adverse cutaneous drug reaction. [2007]

8. England pubmed.ncbi.nlm.nih.gov

Comparing the use of a novel antibiotic-free film-forming topical wound dressing versus a topical triple antibiotic in dermatologic surgical procedures including Mohs micrographic surgery. [2022]

9. United States pubmed.ncbi.nlm.nih.gov

Petrolatum: Barrier repair and antimicrobial responses underlying this "inert" moisturizer. [2021]

10. England pubmed.ncbi.nlm.nih.gov

Healing of porcine donor sites covered with silver-coated dressings. [2006]

11. United States pubmed.ncbi.nlm.nih.gov

Infection and allergy incidence in ambulatory surgery patients using white petrolatum vs bacitracin ointment. A randomized controlled trial. [2022]

12. England pubmed.ncbi.nlm.nih.gov

Understanding wound dressings: foam dressings. [2005]