Middle Meningeal Artery Embolization for Subdural Hematoma
(MESH Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial examines the effectiveness of middle meningeal artery embolization (MMAE) for individuals with chronic subdural hematoma (cSDH), a condition where blood collects on the brain's surface, causing pressure and headaches. Researchers aim to determine the treatment's effectiveness, recurrence rate, and safety. Individuals who have previously received this treatment using common materials like particles or glue may be suitable candidates for the study. As a Phase 2 trial, this research measures the treatment's effectiveness in an initial, smaller group, allowing participants to contribute to early-stage findings.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that this method is safe for treating subdural hematoma?
Research has shown that Middle Meningeal Artery Embolization (MMAE) is generally safe for treating chronic subdural hematoma (CSDH). One study found that this method works well and is tolerated by many patients. Another report noted that serious complications are rare, with only about 4.1% of patients needing additional treatment after the procedure.
While some risks exist, such as a small number of deaths in trials, these were similar to those in groups not receiving the procedure and may not be directly related to MMAE. Overall, MMAE is considered a safe option for managing CSDH, even in older adults.12345Why are researchers excited about this trial?
Middle Meningeal Artery Embolization (MMAE) is unique because it offers a minimally invasive approach to treating chronic subdural hematoma (cSDH), a condition often managed with surgery like burr hole drainage or craniotomy. Unlike these surgical methods, MMAE works by blocking the middle meningeal artery, which can help reduce the bleeding and pressure causing the hematoma. Researchers are excited about MMAE because it potentially reduces recovery time and surgical risks, offering a safer and quicker alternative for patients.
What evidence suggests that middle meningeal artery embolization is effective for subdural hematoma?
Studies have shown that Middle Meningeal Artery Embolization (MMAE) effectively treats chronic subdural hematoma, a condition where blood collects between the brain and its outer covering. Research indicates that MMAE reduces the likelihood of recurrence compared to surgery alone. Some studies even suggest it could become a common treatment option. MMAE is also safe for older adults, making it suitable for those who might not tolerate surgery well. Overall, MMAE shows promise in managing this condition, especially for high-risk patients.23456
Who Is on the Research Team?
David Altschul, MD
Principal Investigator
Montefiore Medical Center
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo Middle Meningeal Artery Embolization (MMAE) for chronic subdural hematoma
Follow-up
Participants are monitored for safety and effectiveness after treatment, including assessment of clinical outcomes and complications
What Are the Treatments Tested in This Trial?
Interventions
- Middle Meningeal Artery Embolization (MMAE)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Montefiore Medical Center
Lead Sponsor
Geisinger Clinic
Collaborator
Heidelberg University
Collaborator
Henri Mondor University Hospital
Collaborator
Ospedale Policlinico San Martino
Collaborator
Ospedale San Raffaele
Collaborator
Lehigh Valley Hospital
Collaborator
Mayo Clinic
Collaborator
Medical University of South Carolina
Collaborator
New York University
Collaborator
Citations
Middle meningeal artery embolization for chronic subdural ...
While surgical intervention is effective, recurrence ranges between 6 and 15% [15, 17, 18, 40, 50]. Middle Meningeal Artery embolization (MMAE) ...
Middle meningeal artery embolization for chronic subdural ...
MMA embolization is safe and effective in the nonagenarian population. · MMA embolization may be applied as primary or adjunctive treatment. · Multiple sedation/ ...
Embolization of the Middle Meningeal Artery for Chronic ...
Among patients with symptomatic chronic subdural hematoma, adjunctive middle meningeal artery embolization resulted in a lower risk of treatment ...
Consensus Statement on Middle Meningeal Artery ...
These results suggest that MMAE plus standard treatment of CSDH shows promising results and may become a standard of care for managing CSDH in ...
Middle Meningeal Artery Embolization for Management of ...
Middle meningeal artery embolization shows promise as an effective option for management of chronic subdural hematoma, particularly in patients at high risk ...
Efficacy and Safety of Middle Meningeal Artery ...
Conclusion: MMA embolization in CSDH management is a safe and effective approach for CSDH. Keywords: Best medical management; Chronic subdural ...
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