Contrast Echocardiography During Exercise to Assess Pulmonary Blood Volume

Overseen By Barry Borlaug, MD

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Mayo Clinic

Disqualifiers: Echo contrast allergy, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 2

800 Participants Needed

Trial Summary

What is the purpose of this trial?

The purpose of this study is to evaluate whether pulmonary blood volume (PBV) derived from contrast echocardiography can serve as a non-invasive surrogate for invasive pulmonary artery wedge pressure (PAWP) during exercise. Also, to compare changes in PBV with exercise in patients with and without heart failure and pulmonary vascular disease.

Research Team

Barry Borlaug, MD

Principal Investigator

Mayo Clinic

Eligibility Criteria

Inclusion Criteria

You are being referred for a heart test called exercise right heart catheterization to check for breathing problems during physical activity.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Exercise Assessment

Participants undergo contrast echocardiography to assess pulmonary blood volume during exercise

1 day

1 visit (in-person)

Rest Assessment

Participants undergo measurements of cardiac output, pulmonary blood volume, and other parameters at rest

1 day

1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after assessments

4 weeks

Treatment Details

Who Is Running the Clinical Trial?

Mayo Clinic

Lead Sponsor

Trials

3,427

Recruited

3,221,000+