19F MRI for Healthy Volunteers
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a new type of MRI, using perfluoropropane gas, to obtain clear lung images. The goal is to enhance imaging technology, enabling doctors to see lung details more clearly. Healthy volunteers who can hold their breath for 16 seconds and have a stable health history are ideal candidates for this study. As an unphased trial, it offers participants the chance to contribute to advancements in medical imaging technology.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the study team or your doctor.
What prior data suggests that this MRI technique is safe for healthy volunteers?
Research has shown that using 19F (a type of gas) in MRI scans is generally safe. One study found that inhaling this gas during an MRI caused no harmful effects. Although not officially approved for inhalation during medical procedures, past reports suggest its safety. Studies involving both healthy individuals and those with conditions like cystic fibrosis also showed no negative side effects from 19F MRI. These findings indicate that this method is safe, though further research could provide additional confirmation.12345
Why are researchers excited about this trial?
Researchers are excited about the use of 19F (perfluoropropane) MRI because it offers a new way to visualize lung function without relying on traditional imaging methods like X-rays or CT scans. Unlike standard imaging, which primarily shows the structure of the lungs, this MRI technique uses a special gas, perfluoropropane, to highlight how air moves and is distributed in the lungs, offering a more dynamic view. This could lead to better understanding and monitoring of lung health, particularly in conditions where traditional imaging falls short in capturing functional changes.
What evidence suggests that 19F MRI is effective for developing lung imaging techniques?
Research has shown that a special type of MRI using ¹⁹F (perfluoropropane) is a promising method for imaging the lungs. Studies have found that this technique consistently provides reliable images. In this trial, healthy volunteers will undergo ¹⁹F MRI to measure how well air moves in and out of the lungs. One study improved the process of capturing these MRI images, making them clearer and faster to obtain. Although researchers are still developing this technique, early results are promising in demonstrating its ability to capture detailed lung images.26789
Are You a Good Fit for This Trial?
This trial is for healthy volunteers between the ages of 18 and 85. The study aims to support advancements in lung imaging technology. Specific eligibility criteria are not provided, but typically participants must be in good health without any major medical conditions.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Imaging and Testing
Participants undergo pulmonary function tests and ¹⁹F (perfluoropropane) MRI to support the development of imaging sequences and evaluate various imaging parameters.
Follow-up
Participants are monitored for any immediate adverse effects post-imaging and testing.
What Are the Treatments Tested in This Trial?
Interventions
- 19F (Perfluoropropane) MRI
Trial Overview
The intervention being tested is a type of lung imaging called ¹⁹F (perfluoropropane) MRI. This study will help improve image quality and develop better hardware for capturing detailed lung images, as well as assess the effectiveness of this technique in measuring pulmonary gas exchange.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Participants will undergo pulmonary function tests, ¹⁹F (perfluoropropane) MRI at the visit.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Alexei Ouriadov
Lead Sponsor
St. Joseph's Health Care London
Collaborator
Citations
Study Details | NCT07305532 | ¹⁹F (Perfluoropropane) MRI
"Healthy volunteers aged 18 to 85 will undergo ¹⁹F (perfluoropropane) MRI to support the development of imaging sequences, reconstruction ...
Reproducibility of 19F‐MR ventilation imaging in healthy ...
In this prospective, ethically approved study, 40 healthy participants were recruited (May 2018‐June 2019) to one of two research sites.
Reproducibility of 19F‐MR ventilation imaging in healthy ...
Conclusion. We demonstrate good reproducibility of %VV measurements in a group of healthy participants using 19F-MRI of inhaled perfluoropropane ...
19F MRI in Healthy Children and Children With Mild Cystic ...
Clinical trial for Cystic Fibrosis in Children , 19F MRI in Healthy Children and Children With Mild Cystic Fibrosis Lung Disease.
Optimized and accelerated 19F‐MRI of inhaled ...
This study demonstrates methods for determining optimal acquisition parameters for 19F‐MRI of inhaled perfluoropropane and shows significant ...
Fluorine (19F) MRS and MRI in biomedicine - PMC
Of particular interest are the paramagnetic relaxation effects imparted by oxygen on 19F nuclei, which cause changes in the spin–lattice relaxation rates (1/T1) ...
Dynamic perfluorinated gas MRI reveals abnormal ...
In this study, we assessed the ability of dynamic 19 F MRI to characterize regional ventilation in healthy volunteers and subjects with CF.
Evaluation of fluorine‐19 magnetic resonance imaging ...
Although OFCB has not been clinically approved for human inhalation, it has no adverse effects based on inhalation. Previous reports by ...
19F Magnetic Resonance Imaging (MRI): From Design of ...
Phantom MRI experiments at 3 T showed a detection limit of 126 mM 19F atom concentration, and in vivo imaging was successfully performed on mice, with a ...
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