Fresh vs Store-Bought Produce for Gut Microbiome

(GFF Trial)

Overseen By Gwynne Mhuireach, PhD

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: University of Oregon

Must not be taking: Antibiotics, Corticosteroids, Cytokines, others

Disqualifiers: BMI, Age, Pregnancy, Immunosuppression, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 1

20 Participants Needed

Trial Summary

What is the purpose of this trial?

The purpose of this research is to explore what types of microbes are present on garden-fresh versus store-bought fruits and vegetables, as well as how they might affect the human gut microbiome.

Research Team

Gwynne Mhuireach, PhD

Principal Investigator

University of Oregon

Eligibility Criteria

This trial is open to adults aged 18-45 with a BMI between 18 and 35, not pregnant or lactating, without a history of cancer (except certain skin cancers), stable bowel movements, no heavy alcohol use, controlled GI disorders, stable diet, no major immune issues or recent heavy drug use for infections.

Inclusion Criteria

Not applicable.

Exclusion Criteria

Body mass index (BMI) greater than or equal to 35 or less than or equal to 18

I am currently pregnant or breastfeeding.

I have had skin cancer treated by surgery but no other cancers.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Intervention

Participants undergo the Supermarket Produce and Garden-fresh Produce interventions in two periods

3 weeks

Baseline, 1 week, 3 weeks

Follow-up

Participants are monitored for changes in fecal bacterial abundance, diversity, and composition

4 weeks

Treatment Details

Interventions

• Garden-fresh Foods
• Supermarket Produce

Trial Overview The study compares the types of microbes on garden-fresh produce versus supermarket produce and their effects on human gut microbiomes. It aims to understand how these different food sources can influence gut health.

Participant Groups

Group I: Supermarket First Experimental Treatment 2 Interventions

Participants assigned to this study arm undergo the Supermarket Produce intervention during the first period and the Garden-fresh Produce intervention during the second period.

Group II: Garden First Experimental Treatment 2 Interventions

Participants assigned to this study arm undergo the Garden-fresh Produce intervention during the first period and the Supermarket Produce intervention during the second period.

Who Is Running the Clinical Trial?

University of Oregon

Lead Sponsor

Trials

91

Recruited

46,700+