Adaptive Radiotherapy for Glioblastoma
(UNITED-4 Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This study builds on the results of prior studies (UNITED and UNITED-3). The goal of UNITED-4 is to test whether an adaptive radiation therapy (RT) therapy approach ('dose painting'), with reduced margins, impacts approach in participants with glioblastoma impacts local control compared to standard non-adaptive RT approach. The main questions of the study are to see how this adaptive RT approach with reduced margins compares to standard RT in terms of:
* Local control
* Overall and progression-free survival
* Patterns of failure
* Toxicity, Neurological Function, and Quality of Life
* Longitudinal imaging features
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive adaptive radiation therapy using MR-Linac with either 30 treatments over 6 weeks or 15 treatments over 3 weeks
Follow-up
Participants are monitored for safety, effectiveness, and quality of life after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Dose painting + Reduced Margins
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Participants in this arm will have radiation (with reduced margins) delivered using a dose painting approach
Find a Clinic Near You
Who Is Running the Clinical Trial?
Sunnybrook Health Sciences Centre
Lead Sponsor
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