Surgical tissue autograft: TPF flap/pericranial flap for Malignant Glioma

Lenox Hill Brain Tumor Center, New York, NY
Targeting 7 different conditionsTissue autograft of pedicled temporoparietal fascial (TPF) or pericranial flap to bypass the blood brain barrier (BBB)N/ARecruitingLed by John Boockvar, MDResearch Sponsored by Northwell Health

Study Summary

This trial is investigating a surgical technique to improve outcomes for people with newly diagnosed brain tumor.

Eligible Conditions
  • Malignant Glioma
  • Glioblastoma
  • Brain Tumor
  • Brain Metastases

Eligibility Criteria

Inclusion Criteria

You will be eligible if you check “Yes” for the criteria below
The surgical procedures called TPFF and pericranial flap can be done successfully for you.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Progression Free Survival (PFS)
Secondary outcome measures
Overall Survival (OS)

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Surgical tissue autograft: TPF flap/pericranial flapExperimental Treatment1 Intervention
Use of a pedicled autologous piece of tissue called the temporoparietal fascial (TPF) flap or pericranial flap into the resection cavity of newly diagnosed glioblastoma multiforme (GBM) patients

Find a site

Who is running the clinical trial?

Northwell HealthLead Sponsor
441 Previous Clinical Trials
467,184 Total Patients Enrolled
John Boockvar, MDPrincipal Investigator
Feinstein Institute for Medical Research/Lenox Hill Hospital
13 Previous Clinical Trials
787 Total Patients Enrolled

Media Library

Tissue autograft of pedicled temporoparietal fascial (TPF) or pericranial flap (Procedure) Clinical Trial Eligibility Overview. Trial Name: NCT05954858 — N/A
Malignant Glioma Research Study Groups: Surgical tissue autograft: TPF flap/pericranial flap
Malignant Glioma Clinical Trial 2023: Tissue autograft of pedicled temporoparietal fascial (TPF) or pericranial flap Highlights & Side Effects. Trial Name: NCT05954858 — N/A
Tissue autograft of pedicled temporoparietal fascial (TPF) or pericranial flap (Procedure) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05954858 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the current enrollment of this experiment?

"Affirmative. shows that this medical experiment, which was first posted on June 29th 2023, is currently recruiting patients. 32 participants need to be recruited from a single centre."

Answered by AI

Is this research initiative taking in new participants?

"Confirming the information accessible on, this trial is actively looking for participants after being originally posted on June 29th 2023 and updated most recently on July 13th of the same year."

Answered by AI
~21 spots leftby Jun 2025