Polyphenols + Exercise for Aging
What You Need to Know Before You Apply
What is the purpose of this trial?
After approximately age 40 years, individuals experience a natural loss of muscle mass, strength, and physical function that is linked to higher risks of falls, disability, loss of independence, and mortality. These losses can also be a precursor to the development of frailty, which includes factors beyond impaired physical function such as cognitive impairment, psychological disorder, increased likelihood of hospitalization, need of long term-care, and mortality. Structured exercise-encompassing both resistance and aerobic training-is widely recognized as an effective lifestyle intervention for improving muscle health, cardiovascular capacity, and overall physical function in older adults. However, aging is accompanied by chronically elevated systemic inflammation, and although exercise remains highly beneficial, older adults exhibit a heightened inflammatory response to training and a diminished capacity for post-exercise recovery.
Polyphenols, a group of naturally occurring bioactive compounds, have been shown to possess both anti-inflammatory and antioxidant benefits, positively impacting recovery and health. Polyphenol supplementation, particularly when paired with structured exercise, may elicit synergistic improvements in physical performance through combined effects on oxidative stress, inflammation, and muscle recovery, making polyphenols a compelling adjunct strategy for mitigating sarcopenia. In pursuit of refining strategies that support healthy aging and preserve functional capacity in older adults, this study aimed to determine the feasibility of implementing a 12-week resistance and aerobic exercise program combined with dietary supplementation in older adults.
Participants will either consume a polyphenol blend or a placebo control of maltodextrin daily whilst undergoing 12 weeks of supervised resistance and aerobic exercise. Additionally, this study will test the hypothesis that polyphenol supplementation will augment the exercise-induced improvements in physical function and muscle health. Further, exploratory analyses of skeletal muscle biopsy and venous plasma samples will aid in elucidating the potential geroprotective effects of polyphenols at both cellular and molecular levels.
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Participants complete baseline assessments including physical function and muscle health measurements
Treatment
Participants undergo a 12-week supervised resistance and aerobic exercise program with daily polyphenol or placebo supplementation
Midpoint Assessment
Participants undergo assessments to evaluate progress at the midpoint of the intervention
Post-intervention Testing
Participants complete post-intervention testing that mirrors baseline procedures
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Polyphenol Rich-Extract
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
12-Week Daily consumption of 3g of Phyto-P (polyphenol-rich extract: chlorogenic acid (30.15 mg), chicoric acid (13.44 mg), 3,4-dicaffeoylquinic acid (8.43 mg), quercetin-3-O-glucoside (15.81 mg), quercetin-3-O-malonyl glucoside (33.00 mg), and anthocyanins (30.57 mg)) taken as capsules starting the first day of 12 weeks of exercise. Supervised group resistance and aerobic exercise performed 4x/week. Resistance band based exercise performed twice per week (2 x 1hr). Aerobic stationary cycling based exercise performed twice per week (2 x 1hr).
12-Week Daily consumption of 3g of maltodextrin taken as capsules starting the first day of 12 weeks of exercise. Supervised group resistance and aerobic exercise performed 4x/week. Resistance band based exercise performed twice per week (2 x 1hr). Aerobic stationary cycling based exercise performed twice per week (2 x 1hr).
Find a Clinic Near You
Who Is Running the Clinical Trial?
Dr. Chris McGlory, PhD
Lead Sponsor
Canadian Frailty Network
Collaborator
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