16 Participants Needed

Botulinum Toxin A for Facial Flushing

Prior Safety DataThis treatment has passed at least one previous human trial

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this study is to find out if botulinum toxin A (botox®) can be used to treat facial flushing.This study is a pilot study designed to determine feasibility of these procedures.

Do I need to stop my current medications for the trial?

The trial requires that you do not use medications that interfere with neuromuscular functions, like certain antibiotics. If you're on such medications, you may need to stop them to participate.

Is Botulinum Toxin A safe for treating facial flushing?

Botulinum Toxin A has been used safely for various skin conditions, including facial flushing, with few side effects reported. It has an excellent safety profile when used for dermatological purposes, although more studies are needed to fully understand its safety in all conditions.12345

How does the drug Botulinum Toxin A differ from other treatments for facial flushing?

Botulinum Toxin A is unique because it works by blocking the release of certain chemicals in the nerves that cause blood vessels to widen, which helps reduce redness and warmth in the skin. Unlike other treatments, it is injected directly into the skin and has shown promising results in improving the quality of life for patients with facial flushing.46789

What data supports the effectiveness of the drug Botulinum Toxin A for treating facial flushing?

Research shows that Botulinum Toxin A can effectively reduce facial flushing, as seen in a study where patients experienced significant improvement in their quality of life after treatment. Additionally, similar success has been observed in treating neck and chest wall flushing, suggesting its potential effectiveness for facial flushing as well.478910

Who Is on the Research Team?

MA

Murad Alam, MD

Principal Investigator

Northwestern University

Are You a Good Fit for This Trial?

This trial is for adults aged 18-65 who experience persistent facial flushing and can give informed consent. It's not suitable for those with certain medical conditions like heart failure, bleeding disorders, or allergies to botox ingredients. Pregnant women, people on specific medications, or those who've had recent cosmetic treatments in the face are excluded.

Inclusion Criteria

Willing and have the ability to understand and provide informed consent for participation in the study and are able to communicate with the study staff.

Exclusion Criteria

You have had congestive heart failure, carcinoid syndrome, mastocystosis, or renal cell carcinoma in the past.
You have received a radiofrequency device treatment in the past 6 months.
You have had problems with bleeding in the past.
See 17 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive botulinum toxin A injections on one side of the face and saline on the other side

8 weeks
Baseline and follow-up visits

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Botulinum Toxin A
Trial Overview The study is testing whether botulinum toxin A (Botox®) injections can help treat facial flushing compared to a saline control. This pilot study aims to assess the feasibility of using Botox for this purpose.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Placebo Group
Group I: botulinum toxin AExperimental Treatment1 Intervention
Group II: Saline ControlPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Northwestern University

Lead Sponsor

Trials
1,674
Recruited
989,000+

Citations

Facial blanching due to neurotoxins: proposed mechanisms. [2013]
Successful use of Botulinum toxin-A for the treatment of neck and anterior chest wall flushing. [2019]
The use of botulinum toxin-A in the management of neck and anterior chest wall flushing: pilot study. [2013]
Botulinum Toxin A in Treatment of Facial Flushing. [2022]
A split-face study using botulinum toxin type B to decrease facial erythema index. [2015]
Adverse Events Associated With Botox as Reported in a Food and Drug Administration Database. [2021]
Unlabeled uses of botulinum toxins: a review, part 2. [2022]
Unlabeled uses of botulinum toxins: a review, part 1. [2022]
Novel cutaneous uses for botulinum toxin type A. [2010]
10.North Macedoniapubmed.ncbi.nlm.nih.gov
Botulin Toxin Use in Rosacea and Facial Flushing Treatment. [2020]
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