Estrogen and Microvascular Function
SH
Overseen ByShona Hang
Age: 18 - 65
Sex: Male
Trial Phase: Academic
Sponsor: Medical College of Wisconsin
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Trial Summary
What is the purpose of this trial?
The goal of this study is to learn how long-term use of estrogen affects blood vessels in healthy adults who were assigned male at birth. Participants will: * give one blood draw of 5 mL * have a camera placed under the tongue to take pictures of blood vessels * have 2 laser Doppler microdialysis catheters placed on the forearm to monitor blood vessels before and after local drug infusion Researchers will compare blood vessel function of those who take estrogen supplements to those who do not.
Eligibility Criteria
Inclusion Criteria
You must be an AMAB individual who has been receiving estrogen therapy for a minimum period of one year.
You are between 18 and 60 years of age.
Your blood pressure is less than 140/90 mmHg.
Treatment Details
Participant Groups
2Treatment groups
Experimental Treatment
Group I: AMAB - continuous estrogenExperimental Treatment3 Interventions
Identify as assigned male at birth (AMAB) who have not had continuous estrogen treatment for a minimum of 1 year.
Group II: AMAB + continuous estrogenExperimental Treatment3 Interventions
Identify as assigned male at birth (AMAB) who have had continuous estrogen treatment for a minimum of 1 year.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Medical College of Wisconsin
Lead Sponsor
Trials
645
Recruited
1,180,000+
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