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Patients undergoing oral immunotherapy for Eosinophilic Esophagitis

N/A
Recruiting
Led By Jonathan M Spergel, MD, PhD
Research Sponsored by Children's Hospital of Philadelphia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 3 month and 6 months
Awards & highlights

Study Summary

Patients with IgE mediated food Allergy have elevated risk of eosinophilic esophagitis, and new therapies like oral immunotherapy (OIT) carry additional risk of Eosinophilic Esophagitis (EoE). The goal of this study is to investigate the Esophageal String Test (EST) as a screening tool for Eosinophilic Esophagitis (EoE) during OIT therapy. Investigators will compare the efficacy of the Esophageal String Test to symptom assessment using a validated patient reported symptom questionnaire, the Pediatric Eosinophilic Esophagitis Symptom Score (PEESS) v2.0. Investigators will utilize these tools to screen patients at their baseline visit prior to the start of OIT, then at the 3- and 6-month OIT follow-up visits.

Eligible Conditions
  • Eosinophilic Esophagitis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 3 month and 6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 3 month and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Esophageal String Test
Secondary outcome measures
Eosinophilic Esophagitis Symptoms
Prevalence of Eosinophilic Esophagitis

Trial Design

1Treatment groups
Experimental Treatment
Group I: Patients undergoing oral immunotherapyExperimental Treatment1 Intervention
All patients will have esophageal string test

Find a Location

Who is running the clinical trial?

Children's Hospital of PhiladelphiaLead Sponsor
710 Previous Clinical Trials
8,588,833 Total Patients Enrolled
4 Trials studying Eosinophilic Esophagitis
5,362 Patients Enrolled for Eosinophilic Esophagitis
Jonathan M Spergel, MD, PhDPrincipal InvestigatorChildren's Hospital of Philadelphia
3 Previous Clinical Trials
5,390 Total Patients Enrolled
1 Trials studying Eosinophilic Esophagitis
5,300 Patients Enrolled for Eosinophilic Esophagitis

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who else is applying?

What site did they apply to?
The Children's Hospital of Philadelphia
What portion of applicants met pre-screening criteria?
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
Esophageal String Test Monitoring to Monitor Eosinophilic Esophagitis During Oral Immunotherapy
Jonathan Spergel 2024. "Esophageal String Test Monitoring to Monitor Eosinophilic Esophagitis During Oral Immunotherapy". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06389994.
All > Paid Studies Baltimore > Philadelphia
~50 spots leftby Apr 2026
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