Esophageal String Test Monitoring to Monitor Eosinophilic Esophagitis During Oral Immunotherapy
What You Need to Know Before You Apply
What is the purpose of this trial?
Patients with IgE mediated food Allergy have elevated risk of eosinophilic esophagitis, and new therapies like oral immunotherapy (OIT) carry additional risk of Eosinophilic Esophagitis (EoE). The goal of this study is to investigate the Esophageal String Test (EST) as a screening tool for Eosinophilic Esophagitis (EoE) during OIT therapy. Investigators will compare the efficacy of the Esophageal String Test to symptom assessment using a validated patient reported symptom questionnaire, the Pediatric Eosinophilic Esophagitis Symptom Score (PEESS) v2.0. Investigators will utilize these tools to screen patients at their baseline visit prior to the start of OIT, then at the 3- and 6-month OIT follow-up visits.
Who Is on the Research Team?
Jonathan M Spergel, MD, PhD
Principal Investigator
Children's Hospital of Philadelphia
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Baseline assessment using the Esophageal String Test and PEESS questionnaire before starting OIT
Treatment
Participants undergo oral immunotherapy with monitoring using the Esophageal String Test and PEESS at 3 and 6 months
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
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Who Is Running the Clinical Trial?
Children's Hospital of Philadelphia
Lead Sponsor