Nodal Sampling for Endometrial Cancer
Trial Summary
What is the purpose of this trial?
This study aims to estimate the recurrence-free survival rates in women with endometrial cancer treated with selective versus sentinel node surgical staging. This study will gather information to help determine the best way to evaluate lymph nodes during surgery for endometrial cancer.
Will I have to stop taking my current medications?
The trial protocol does not specify whether you need to stop taking your current medications. However, if you are on chemotherapy, hormone therapy, or immunotherapy for your endometrial cancer, you cannot participate in the trial.
What data supports the effectiveness of the treatment REFLEX, Selective surgical staging, for endometrial cancer?
Research shows that sampling lymph nodes (small glands that are part of the immune system) can help determine the spread of endometrial cancer, which is important for planning treatment. Studies suggest that this approach can improve survival outcomes by accurately assessing cancer spread, especially in high-risk cases.12345
Is nodal sampling for endometrial cancer safe for humans?
How is the treatment 'Selective surgical staging' unique for endometrial cancer?
Selective surgical staging for endometrial cancer involves sampling specific lymph nodes (small glands that are part of the immune system) to check for cancer spread, which can help tailor treatment to the patient's risk level. This approach is different from more extensive surgeries that remove many lymph nodes, potentially reducing complications and recovery time.234910
Research Team
Rachel Miller, M.D.
Principal Investigator
University of Kentucky
Eligibility Criteria
This trial is for women with endometrial cancer confined to the uterus, who can undergo surgery and have a life expectancy of at least 6 months. They should understand the study and consent to participate. Prior chemotherapy is okay if it was over five years ago with no current disease. Women must not be pregnant, have had prior pelvic lymphadenectomy or irradiation, or severe allergies to iodine/ICG.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Surgical Staging
Participants undergo selective surgical staging or sentinel node procedure for lymph node evaluation
Follow-up
Participants are monitored for recurrence-free survival, progression-free survival, and overall survival
Treatment Details
Interventions
- REFLEX
- Selective surgical staging
Find a Clinic Near You
Who Is Running the Clinical Trial?
Rachel Miller
Lead Sponsor