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Vitamin C for Acute Pain

Led By Raoul Daoust, MD MSc
Research Sponsored by Hopital du Sacre-Coeur de Montreal
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Discharged with an opioid prescription
Be older than 18 years old
Screening 3 weeks
Treatment Varies
Follow Up 3 months
Awards & highlights

Study Summary

This trial aims to study whether taking vitamin C can reduce the amount of opioid pills needed for pain relief in patients discharged from the emergency department with acute musculoskeletal pain. The study will compare the use

Who is the study for?
This trial is for adults over 18 who visited the emergency department (ED) with musculoskeletal pain that's been there for less than two weeks. They must have left the ED with a prescription for opioids and be able to speak French or English.Check my eligibility
What is being tested?
The study tests if taking vitamin C reduces opioid use after an ED visit for acute musculoskeletal pain. Participants will either receive 1000 mg of vitamin C twice daily or a placebo, over two weeks, and track their opioid intake and pain levels.See study design
What are the potential side effects?
Vitamin C is generally considered safe but can sometimes cause digestive issues like heartburn, stomach cramps, nausea, or diarrhea at high doses.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
I was prescribed opioids when I was discharged.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Contraceptives, Oral
Secondary outcome measures
Average pain relief
Limb structure
Incidence of chronic pain (including complex regional pain syndrome (CRPS)) globally and for each type of MSK pain
+4 more

Side effects data

From 2018 Phase 2 trial • 20 Patients • NCT03148236
Study treatment Arm
Vitamin C

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Vitamin CExperimental Treatment1 Intervention
1 000 mg vitamin C taken orally twice a day
Group II: PlaceboPlacebo Group1 Intervention
Matching placebo
First Studied
Drug Approval Stage
How many patients have taken this drug
Vitamin C
Completed Phase 4

Find a Location

Who is running the clinical trial?

Hopital de l'Enfant-JesusOTHER
16 Previous Clinical Trials
5,358 Total Patients Enrolled
2 Trials studying Acute Pain
2,786 Patients Enrolled for Acute Pain
Hopital du Sacre-Coeur de MontrealLead Sponsor
51 Previous Clinical Trials
11,805 Total Patients Enrolled
3 Trials studying Acute Pain
3,547 Patients Enrolled for Acute Pain
Raoul Daoust, MD MScPrincipal InvestigatorUniversité de Montréal
3 Previous Clinical Trials
3,547 Total Patients Enrolled
3 Trials studying Acute Pain
3,547 Patients Enrolled for Acute Pain

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are participants currently being recruited for this clinical trial?

"As documented on clinicaltrials.gov, this investigation is presently seeking eligible participants. Initially shared on November 1st, 2023, the last revision was made on February 23rd, 2024."

Answered by AI

What is the total number of individuals actively engaged in this medical study?

"Indeed, the details on clinicaltrials.gov indicate that this investigation is presently enrolling participants. Initially shared on November 1st, 2023, and last revised on February 23rd, 2024, this study aims to recruit a total of 464 patients at a single site."

Answered by AI
~309 spots leftby Jun 2025