VOR Precision Training for Vestibular Disorders
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how noise affects balance and movement in individuals with vestibular disorders and examines whether the brain can improve balance signals through VOR precision training, a specialized therapy. It targets those with peripheral vestibular damage, such as from vestibular schwannoma (a type of tumor affecting balance nerves), and tests them before and after surgery. Healthy individuals with no history of balance or ear problems participate as a comparison group. Suitable candidates include patients with specific vestibular damage, like vestibular schwannoma, or individuals without any prior inner ear or neurological issues. As an unphased trial, this study provides a unique opportunity to contribute to foundational research that may lead to new therapies for vestibular disorders.
Will I have to stop taking my current medications?
If you are taking vestibular suppressant medications like benzodiazepines, antihistamines, or anticholinergics, you will need to stop taking them to participate in this trial.
What prior data suggests that VOR precision training is safe for vestibular disorders?
Research has shown that VOR precision training, which aids balance and eye movements, is generally well-tolerated. Some studies suggest that after five weeks of similar training, participants experience improved balance and eye control without major side effects. Other findings indicate that VOR precision improves with training over time, and this improvement is expected to be safe.
As this trial is in an early stage, it primarily examines how well the brain can adapt to enhance balance and eye coordination. While detailed safety data is still limited, early-stage trials typically continue to gather this information. Overall, initial research suggests the training is likely safe, but discussing the most current details with the trial team is advisable.12345Why are researchers excited about this trial?
Researchers are excited about VOR precision training for vestibular disorders because it offers a new way to improve balance and dizziness issues by focusing on precision eye movement exercises. Unlike traditional treatments that might rely on medication or physical therapy to broadly address symptoms, this method specifically targets the vestibulo-ocular reflex (VOR), which is crucial for maintaining stable vision during head movements. By training the VOR directly, this approach has the potential to offer more targeted and effective symptom relief, particularly for patients with specific types of vestibular damage.
What evidence suggests that VOR precision training is effective for vestibular disorders?
Research has shown that VOR precision training can improve balance and eye movement in people with inner ear disorders. In this trial, participants with peripheral vestibular dysfunction, including those with vestibular schwannoma, will undergo VOR precision training. One study found that balance problems in patients with vestibular schwannoma (a type of ear tumor) are linked to the effectiveness of their VOR (Vestibulo-Ocular Reflex). This reflex helps maintain steady vision during head movements. Early results suggest that training enhances VOR precision, potentially leading to better balance and reduced dizziness. This improvement is expected to be noticeable compared to their abilities before training.23678
Are You a Good Fit for This Trial?
This trial is for people with certain inner ear conditions like Vestibular Schwannoma, requiring surgery, or healthy individuals with normal vestibular function and hearing. Participants should not have other ear or neurological diseases (except migraines) and must not be taking medication that affects the vestibular system.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Pre-operative Assessment
Assessment of vestibular precision in patients with vestibular schwannoma before surgery
Sub-acute Post-operative Assessment
Assessment of vestibular precision 6 weeks after vestibular nerve surgery
Chronic Post-operative Assessment
Assessment of vestibular precision 6 months after vestibular nerve surgery
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- VOR precision training
Find a Clinic Near You
Who Is Running the Clinical Trial?
Massachusetts Eye and Ear Infirmary
Lead Sponsor