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Mechanistic Interventions for Dissociative Disorders (MIND Trial)

N/A
Recruiting
Led By Greg Siegle, PhD
Research Sponsored by Emory University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, week 6 (post-intervention), 3 months post-intervention, 6 months post-intervention
Awards & highlights

MIND Trial Summary

This trial will test whether different interventions can change the neural networks associated with attentional control and interoceptive awareness in people who have dissociative symptoms from trauma.

Who is the study for?
This trial is for people who feel disconnected from themselves (dissociation) after a traumatic event and score at least 7 on the MDI depersonalization scale. Participants must have experienced significant trauma as defined by DSM-5 criteria and be willing to join the study. Those with severe substance dependence, active psychosis, or serious cognitive issues cannot participate.Check my eligibility
What is being tested?
The study tests if focusing on breathing without distractions or using vibration can influence brain networks related to attention control and body awareness in traumatized individuals with dissociative symptoms. It's conducted at Emory University and University of Pittsburgh.See study design
What are the potential side effects?
Potential side effects are not explicitly mentioned but may include discomfort due to focus exercises or vibrations, emotional distress from recalling traumatic events during assessments, or fatigue from participation.

MIND Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, week 6 (post-intervention), 3 months post-intervention, 6 months post-intervention
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, week 6 (post-intervention), 3 months post-intervention, 6 months post-intervention for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Affective Number Stroop (ANS) Task Performance
Change in Attentional Control Scale (ACS) Score
Change in Change in Life Events Checklist Score
+44 more

MIND Trial Design

4Treatment groups
Experimental Treatment
Group I: Vibration With Breath FocusExperimental Treatment2 Interventions
Participants receiving the vibration with breath focus study intervention.
Group II: VibrationExperimental Treatment1 Intervention
Participants receiving the vibration study intervention.
Group III: Screens FreeExperimental Treatment1 Intervention
Participants receiving the screens free study intervention.
Group IV: Breath FocusExperimental Treatment1 Intervention
Participants receiving the breath focus study intervention.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Vibration
2016
Completed Phase 2
~740

Find a Location

Who is running the clinical trial?

National Center for Complementary and Integrative Health (NCCIH)NIH
832 Previous Clinical Trials
668,733 Total Patients Enrolled
1 Trials studying Dissociation
24 Patients Enrolled for Dissociation
Emory UniversityLead Sponsor
1,638 Previous Clinical Trials
2,560,332 Total Patients Enrolled
Greg Siegle, PhDPrincipal InvestigatorUniversity of Pittsburgh

Media Library

Breath Focus Clinical Trial Eligibility Overview. Trial Name: NCT04670640 — N/A
Dissociation Research Study Groups: Vibration, Vibration With Breath Focus, Screens Free, Breath Focus
Dissociation Clinical Trial 2023: Breath Focus Highlights & Side Effects. Trial Name: NCT04670640 — N/A
Breath Focus 2023 Treatment Timeline for Medical Study. Trial Name: NCT04670640 — N/A
Dissociation Patient Testimony for trial: Trial Name: NCT04670640 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any vacancies available for this research endeavor?

"Affirmative. Evidence on clinicaltrials.gov reveals that this trial, which was initially listed to the public on September 18th 2021, is currently in need of volunteers. 200 people are necessary across two sites for successful completion of the study."

Answered by AI

How many individuals have enrolled for this experiment?

"Correct. According to the clinicaltrials.gov website, this medical trial is actively recruiting volunteers with a start date of September 18th 2021 and an end date of February 4th 2022. A total of 200 participants will be recruited from two separate sites."

Answered by AI

Who qualifies to take part in this investigation?

"This medical investigation is in search of 200 participants aged 18-65 who experience dissociation. Additional qualifications include a DSM-5 Criterion A trauma (verified via the Life Events Checklist) as well as a Multiscale Dissociation Inventory (MDI) depersonalization subscale score of 7 or higher, and being willing to partake in this trial."

Answered by AI

Can participants aged eighty and above take part in this trial?

"The minimum age for participation in this medical trial is 18 and the upper limit of eligible participants extends to 65 years old."

Answered by AI

Who else is applying?

What state do they live in?
Georgia
Pennsylvania
What site did they apply to?
Grady Hospital
Western Psychiatric Institute and Clinic
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
0

Why did patients apply to this trial?

I want to use my life experiences to help others. I also have a general interest in research and would find it fun and useful.
PatientReceived 1 prior treatment

What questions have other patients asked about this trial?

Will you be asking me to consume anything unnatural?
PatientReceived 2+ prior treatments
Recent research and studies
clinicaltrials.govStudy
Mechanistic Interventions and Neuroscience of Dissociation
Negar Fani 2021. "Mechanistic Interventions and Neuroscience of Dissociation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04670640.
~81 spots leftby Jan 2026
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