Biomarker-Supported Antibiotics for Critical Care
(BAST-ICU Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this randomized clinical trial is to determine whether a biomarker-signature (BV) supported antibiotic treatment decision matrix can have a beneficial impact on antibiotic use and patient outcomes in an ICU population.
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive antibiotic treatment based on either clinical assessment alone or combined with BV-signature test results
Follow-up
Participants are monitored for safety and effectiveness after treatment, including assessment of adverse events and clinical outcomes
What Are the Treatments Tested in This Trial?
Interventions
- Biomarker-signature supported antibiotic treatment recommendation
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
The result of the BV test will be unmasked for the investigators and combined with the clinical assessment of the antibiotic prescription, using a decision matrix. The recommendation will be shared with the treating team.
Participants in the control group will have antibiotic treatment recommendations based on clinical assessment alone. The BV-signature test result will remain hidden.
Find a Clinic Near You
Who Is Running the Clinical Trial?
McGill University Health Centre/Research Institute of the McGill University Health Centre
Lead Sponsor
Canadian Institutes of Health Research (CIHR)
Collaborator
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