Diet for Diabetic Neuropathy
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this clinical trial is to determine whether targeted nutritional changes can improve symptoms of painful diabetic neuropathy. Impaired blood flow to peripheral nerves-resulting in reduced oxygen delivery and subsequent nerve injury-is a well-established contributor to neuropathy. Prior studies have shown that a whole-food, plant-based diet without added oils can improve or even reverse arterial disease, suggesting a potential mechanism for enhancing nerve perfusion and function.
This study is a randomized controlled trial comparing a whole-food, plant-based diet with standard pharmacologic management for painful diabetic neuropathy.
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants are randomized to either a whole-food, plant-based diet or standard pharmacologic management for painful diabetic neuropathy over a two-month period
Crossover
Participants in the conventional management group have the option to cross over to the dietary intervention after two months
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Whole-Food, Plant-Based Diet
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
This approach reflects standard pharmacologic management of diabetic peripheral neuropathy. Commonly used medications include antiepileptic agents (gabapentin, pregabalin), serotonin-norepinephrine reuptake inhibitors (e.g., duloxetine), tricyclic antidepressants (e.g., amitriptyline, nortriptyline), and over-the-counter options such as alpha-lipoic acid and turmeric.
This is a whole food plant-based diet that excludes meat, dairy, eggs and oil
Find a Clinic Near You
Who Is Running the Clinical Trial?
AdventHealth
Lead Sponsor
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