120 Participants Needed

Home-Based Exercise for Diabetes & Chronic Kidney Disease

(Fantastic Trial)

DM
Overseen ByDiana Mager, PhD MSc RD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Alberta
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

One of the most common problems in people with diabetes (DM) and chronic kidney disease (CKD) is the high frequency of other coinciding medical conditions such as osteoporosis and frailty. Frailty in particular is very common in adults with DM and CKD and it can result in significant muscle weakness which can result in increasing difficulties with performing activities of daily life (ADL). This can lead to an increase risk for falls, bone fractures and increasing hospitalization. The investigators have showed that adults with DM and CKD who have frailty use hospital services more frequently, have reduced quality of life and difficulties with performing their ADLs1. There is some evidence that early screening for frailty and lifestyle interventions that focus on healthier eating and physical activity can help prevent frailty from getting worse. The study purpose is to develop and test a home-based lifestyle intervention program focused on optimizing diet and the ability to perform your ADLs in adults with DM and CKD. The goal of this program is to ensure that adults with DM can live healthier lives within the community.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It is best to discuss this with the trial coordinators or your doctor.

Is resistance exercise safe for people with chronic kidney disease?

Resistance exercise is generally safe for people with chronic kidney disease, as studies show it can improve muscle strength and quality of life without causing side effects like injuries or hospitalizations.12345

How is resistance exercise unique as a treatment for diabetes and chronic kidney disease?

Resistance exercise is unique because it focuses on building muscle strength and size, which can improve physical function and quality of life for patients with chronic kidney disease and diabetes. Unlike other treatments, it may also help with nutritional status, insulin sensitivity, and overall well-being, making it a noninvasive and cost-effective option.15678

What data supports the effectiveness of the treatment Resistance Exercise, Resistance Training, Strength Training for diabetes and chronic kidney disease?

Research shows that resistance exercise can improve muscle mass, strength, and physical function, which are beneficial for people with chronic kidney disease. It may also help with better glucose control and improve overall quality of life, making it a promising treatment for those with diabetes and kidney issues.4591011

Who Is on the Research Team?

DM

Diana Mager, PhD MSc RD

Principal Investigator

University of Alberta

Are You a Good Fit for This Trial?

This trial is for adults aged 50-85 with Type 2 diabetes and moderate chronic kidney disease (not on dialysis). Participants should be able to perform resistance exercises and have no severe cognitive impairments, vision loss, recent bone fractures, or muscular disorders that limit mobility.

Inclusion Criteria

I am between 50 and 85 years old.
I have Type 2 diabetes and my kidney function is reduced but not severely.

Exclusion Criteria

You have difficulties with thinking and remembering things.
I cannot do exercises like walking or standing up from a chair due to severe joint issues.
I am on dialysis for kidney disease.
See 3 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks
1 visit (in-person)

Development of Video Programming

Home video content is developed focusing on resistance exercise and nutrition literacy

2 months

Open-label Non-blinded Study

Participants undergo frailty screening and are randomized to intervention or control groups

6 months
Baseline and 6-month visits (in-person), monthly home visits

Follow-up

Participants are monitored for changes in frailty status, cognitive health, and quality of life

6 months

What Are the Treatments Tested in This Trial?

Interventions

  • Resistance Exercise
Trial Overview The study is testing a home-based lifestyle program aimed at improving diet and daily activity in adults with diabetes and kidney disease. The goal is to prevent frailty-related issues like muscle weakness, falls, fractures, and hospitalizations.
How Is the Trial Designed?
4Treatment groups
Experimental Treatment
Active Control
Group I: Exercise Intervention Pre-FrailExperimental Treatment1 Intervention
Group II: Exercise Intervention FrailExperimental Treatment1 Intervention
Group III: Standard of Care or Control FrailActive Control1 Intervention
Group IV: Standard of Care or Control Pre-FrailActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Alberta

Lead Sponsor

Trials
957
Recruited
437,000+

Published Research Related to This Trial

A 6-month home-based exercise program significantly improved physical functioning in patients with Stage 4 chronic kidney disease (CKD), as evidenced by a greater increase in the incremental shuttle walking test compared to a control group.
The exercise program also enhanced health-related quality of life (HRQOL) in several domains, including work status and social interaction, while showing potential benefits on kidney function and related biomarkers.
Home-based aerobic exercise and resistance training for severe chronic kidney disease: a randomized controlled trial.Uchiyama, K., Adachi, K., Muraoka, K., et al.[2022]
Resistance or strength exercise training can significantly improve muscle mass, strength, and function in patients with chronic renal failure, potentially reversing malnutrition and delaying disease progression.
Even with low dietary protein intake, resistance training enhances protein metabolism and overall physical function, suggesting it could be a valuable, noninvasive treatment option for improving the quality of life in renal patients.
Potential benefits of resistance exercise training on nutritional status in renal failure.Castaneda, C., Grossi, L., Dwyer, J.[2019]
Exercise training has been shown to significantly improve physical function, fitness, and quality of life in individuals with chronic kidney disease, yet it is not commonly included in standard kidney care programs.
To integrate exercise rehabilitation into kidney care, it is essential to focus on clinically relevant outcomes for patients, implement evidence-based strategies, and treat exercise as a legitimate medical therapy.
Advancing Exercise Science for Better Health Outcomes Across the Spectrum of Chronic Kidney Disease.Bohm, C., Bennett, P., Lambert, K., et al.[2023]

Citations

Home-based aerobic exercise and resistance training for severe chronic kidney disease: a randomized controlled trial. [2022]
Potential benefits of resistance exercise training on nutritional status in renal failure. [2019]
Advancing Exercise Science for Better Health Outcomes Across the Spectrum of Chronic Kidney Disease. [2023]
Exercise as a therapeutic intervention in chronic kidney disease: are we nearly there yet? [2023]
Home-Based Exercise for People With Chronic Kidney Disease: A Systematic Review and Meta-Analysis. [2022]
A comparison of aerobic exercise and resistance training in patients with and without chronic kidney disease. [2022]
A Trial of Lifestyle Modification on Cardiopulmonary, Inflammatory, and Metabolic Effects among Obese with Chronic Kidney Disease. [2018]
Effects of a resistance training program in kidney transplant recipients: A randomized controlled trial. [2021]
Resistance training in hemodialysis patients: a review. [2015]
[Effect of resistance exercise intradialytic in renal patients chronic in hemodialysis]. [2019]
Exercise and chronic kidney disease: current recommendations. [2022]
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