Tailored DPP Intervention for Prediabetes
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this study is to enhance reach and uptake of diabetes prevention among young adults, with a focus on recruiting underserved and high-need students who face additional challenges, including food and financial insecurity.The specific aims are to: 1) Evaluate the efficacy of adolescents and young adults (AYA)-tailored version of the University of California Diabetes Prevention Program (UC DPP) for mitigating type 2 diabetes risk (i.e., weight change) in a pre/post pilot trial. The investigators hypothesize that the AYA-tailored intervention will be effective at producing 5% weight loss from baseline to program completion (at 9-months); and, 2) Assess the feasibility and acceptability of an AYA-tailored version of the UC DPP program. The investigators hypothesize that it will be feasible to recruit the desired number of participants given proposed innovative outreach strategies, and that the AYA-tailored intervention will be deemed acceptable to participants both qualitatively and in regards to their retention in the program at rates similar to the larger UC DPP.The investigators will randomize participants to the AYA-tailored DPP cohort vs control cohort. Control participants will be offered the opportunity to participate in the AYA-tailored DPP in the following academic year. Participants will be organized into groups within their DPP cohort based on their student status and/or place of residence. The intervention will include 19 sessions (18 in-person and 1 on-demand) covering 24 DPP modules; each session is approximately an hour in length and will be moderated by a lifestyle coach. At the end of each session, intervention participants will receive an email/text with a unique link to a brief REDCap survey to ascertain acceptability of the session. Control group will receive access to materials about study habits, alcohol use, and financial literacy. Control group will receive materials via e-mail for participants to review on their own time and will receive acceptability surveys. A research assistant (RA) will meet with control participants via Zoom to explain the materials. Participants will complete baseline and 9-month follow-up assessments. Participants will complete a 30 minute questionnaire via REDCap and height/weight measurements will be collected by a RA. Participants will be asked to self-report weight and physical activity at the end of the fall and winter quarter; data will be collected via brief REDCap survey.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
Is the Tailored DPP Intervention generally safe for humans?
DPP-4 inhibitors, which are part of the Tailored DPP Intervention, have been used for over 10 years in diabetes treatment and are generally considered safe. They do not increase the risk of major heart events and have a favorable safety profile, with ongoing studies to monitor any potential side effects like pancreatitis or hypoglycemia.12345
How is the Tailored DPP Intervention treatment different from other treatments for prediabetes?
The Tailored DPP Intervention is unique because it adapts the traditional Diabetes Prevention Program (DPP) using technology, such as daily text messaging and Fitbit devices, to make it more accessible and easier to follow compared to in-person programs. This approach aims to overcome barriers like the commitment to a yearlong program by offering a more flexible and convenient option for people with prediabetes.678910
What data supports the effectiveness of the treatment Tailored DPP Intervention for prediabetes?
The Tailored DPP Intervention is based on the Diabetes Prevention Program (DPP), which has been shown to prevent or delay type 2 diabetes in people with prediabetes. Additionally, a study found that using technology like text messaging and fitness trackers to deliver DPP content can effectively support lifestyle changes in primary care settings.1011121314
Who Is on the Research Team?
Lauren Wisk, PhD
Principal Investigator
University of California, Los Angeles
Are You a Good Fit for This Trial?
This trial is for young adults at risk of type 2 diabetes, particularly those who are underserved and dealing with challenges like food and financial insecurity. Participants should be students willing to engage in a program aimed at preventing diabetes.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive the AYA-tailored Diabetes Prevention Program intervention, including 19 sessions over the academic year
Control
Control group receives materials on study habits, alcohol use, and financial literacy via email, with Zoom sessions for explanation
Follow-up
Participants are monitored for changes in weight and quality of life at 9-month follow-up
What Are the Treatments Tested in This Trial?
Interventions
- Tailored DPP Intervention
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Los Angeles
Lead Sponsor
American Diabetes Association
Collaborator