20 Participants Needed

Aerobic vs Resistance Exercise for Type 1 Diabetes

Recruiting at 1 trial location
JE
Overseen ByJane E Yardley, PhD
Age: 18+
Sex: Female
Trial Phase: Academic
Sponsor: University of Alberta
Must be taking: Insulin
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

Participants will be asked to wear a continuous glucose monitor for at least three days on three separate occasions. One testing session will be a no-exercise resting control session (90 minutes). One will be a moderate aerobic exercise session (30 minutes of exercise, 60 minutes of recovery), and the third will be a moderate weight-lifting session (\~30 minutes of exercise, 60 minutes of recovery).The investigators will measure changes in blood glucose during exercise by drawing blood during and after exercise. Post-exercise glucose trends will be examined using continuous glucose monitoring.

Will I have to stop taking my current medications?

The trial requires that you do not use medications (other than insulin) that affect glucose metabolism. If you are taking such medications, you may need to stop them to participate.

Is exercise safe for people with type 1 diabetes?

Both aerobic (like running or cycling) and resistance exercises (like weight lifting) are generally safe for people with type 1 diabetes, but they can affect blood sugar levels differently. Aerobic exercise may lower blood sugar, increasing the risk of hypoglycemia (low blood sugar), while resistance exercise can help stabilize it. It's important to monitor blood sugar levels and adjust insulin or food intake as needed when exercising.12345

How does aerobic vs resistance exercise treatment differ for type 1 diabetes?

This treatment is unique because it combines aerobic (like running or cycling) and resistance exercises (like weight lifting) to help manage type 1 diabetes. Unlike other treatments, this approach can prevent blood sugar drops during exercise and improve overall health, including cardiovascular and psychological benefits.12367

What data supports the effectiveness of this treatment for type 1 diabetes?

Research shows that both aerobic and resistance exercises can help people with type 1 diabetes by improving diabetes control and reducing the risk of heart-related issues. Adding resistance training to regular aerobic exercise may further enhance blood sugar management and overall health.128910

Are You a Good Fit for This Trial?

This trial is for post-menopausal women with Type 1 Diabetes who can exercise and visit the lab in Edmonton. They should have stable diabetes management, no severe complications like heart disease or neuropathy, not smoke, drink heavily, or be significantly overweight.

Inclusion Criteria

I have been diagnosed with type 1 diabetes for over a year.
I have been in menopause for at least a year or have had my uterus and ovaries removed.
Able to visit the lab in Edmonton, Alberta (University of Alberta)
See 1 more

Exclusion Criteria

Your blood pressure is higher than 140 over 95.
I am taking medication that affects my blood sugar, not including insulin.
I have a history of heart disease.
See 8 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Pre-test Measures

Participants undergo pre-test measures including questions related to menopause, PA levels, medication, blood pressure, heart rate, anthropometric characteristics, HbA1c assessment, maximal aerobic capacity test, strength test, and DXA scan.

1-2 weeks

Testing Sessions

Participants complete three testing sessions: a no-exercise resting control session, a moderate aerobic exercise session, and a moderate resistance exercise session. Blood samples are drawn, and continuous glucose monitoring is conducted.

3 sessions over 1-2 weeks
3 visits (in-person)

Follow-up

Participants are monitored for changes in blood glucose and other secondary outcomes using continuous glucose monitoring for up to 24 hours post-exercise.

1-2 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Aerobic Exercise
  • No exercise
  • Resistance Exercise
Trial Overview The study compares how moderate aerobic exercise (like walking), resistance training (like weight-lifting), and no exercise affect blood sugar levels in these women. Blood samples will be taken during and after sessions to monitor glucose changes.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: All participantsExperimental Treatment3 Interventions
All participants will take part in all three testing conditions

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Alberta

Lead Sponsor

Trials
957
Recruited
437,000+

Women and Children's Health Research Institute, Canada

Collaborator

Trials
18
Recruited
24,800+

Published Research Related to This Trial

In a study of 21 non-physically active men with long-lasting type 1 diabetes, both aerobic and resistance training were found to be safe and did not significantly affect glycemic control or cardiovascular risk factors over three months.
While neither exercise type led to significant changes in HbA1c levels, there was a slight downward trend in the aerobic group, suggesting potential benefits that may require further investigation.
Aerobic as well as resistance exercises are good for patients with type 1 diabetes.Wróbel, M., Rokicka, D., Czuba, M., et al.[2022]
The READI trial involved 131 physically active adults with type 1 diabetes and aimed to determine if adding a 6-month resistance training program would improve glycemic control compared to aerobic exercise alone.
This study is significant as it is the first to assess the additional health benefits of resistance training in individuals with type 1 diabetes who are already engaged in aerobic exercise, potentially influencing future exercise recommendations for this population.
Resistance Exercise in Already-Active Diabetic Individuals (READI): study rationale, design and methods for a randomized controlled trial of resistance and aerobic exercise in type 1 diabetes.Yardley, JE., Kenny, GP., Perkins, BA., et al.[2022]
Resistance training is an important addition to exercise programs for individuals with diabetes, as it enhances muscular conditioning and overall health.
The article provides guidelines for safely prescribing resistance training for people with diabetes, considering both those with and without vascular complications, ensuring effective and safe exercise regimens.
Resistance training guidelines for individuals with diabetes mellitus.Soukup, JT., Maynard, TS., Kovaleski, JE.[2017]

Citations

Aerobic as well as resistance exercises are good for patients with type 1 diabetes. [2022]
Resistance Exercise in Already-Active Diabetic Individuals (READI): study rationale, design and methods for a randomized controlled trial of resistance and aerobic exercise in type 1 diabetes. [2022]
Resistance training guidelines for individuals with diabetes mellitus. [2017]
Effects of performing resistance exercise before versus after aerobic exercise on glycemia in type 1 diabetes. [2021]
The Resistance Exercise in Already Active Diabetic Individuals (READI) Randomized Clinical Trial. [2023]
Resistance exercise in type 1 diabetes. [2013]
Insulin-sensitivity response to a single bout of resistive exercise in type 1 diabetes mellitus. [2019]
Effect of Combined Exercise Versus Aerobic-Only Training on Skeletal Muscle Lipid Metabolism in a Rodent Model of Type 1 Diabetes. [2018]
Once-weekly supervised combined training improves neurocognitive and psychobehavioral outcomes in young patients with type 1 diabetes mellitus. [2020]
10.United Statespubmed.ncbi.nlm.nih.gov
Examining the Acute Glycemic Effects of Different Types of Structured Exercise Sessions in Type 1 Diabetes in a Real-World Setting: The Type 1 Diabetes and Exercise Initiative (T1DEXI). [2023]
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top
Terms of Service·Privacy Policy·Cookies·Security