Neurofeedback for Depression
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a new treatment approach using real-time fMRI neurofeedback to reduce depression in people with Major Depressive Disorder (MDD). Advanced brain imaging provides feedback and adjusts tasks based on the participant's brain activity, potentially improving mood. The trial includes two groups: one receives actual neurofeedback, while the other gets a placebo version. It suits adults experiencing depression symptoms who aren't currently on antidepressants or in therapy. As an unphased trial, this study allows participants to contribute to innovative research that could lead to new treatment options for depression.
Will I have to stop taking my current medications?
Yes, you will need to stop taking any psychoactive medications, including antidepressants, to participate in this trial.
What prior data suggests that this neurofeedback technique is safe for treating depression?
Research has shown that real-time fMRI neurofeedback is safe for people with depression. Studies indicate that this treatment is generally well-tolerated, with few reports of serious side effects. Some participants have noticed improvements in their symptoms, suggesting that the treatment may help reduce depression symptoms. Overall, evidence suggests that fMRI neurofeedback therapy is a safe option for those considering joining a clinical trial.12345
Why are researchers excited about this trial?
Most treatments for depression, like antidepressants and therapy, focus on altering brain chemistry or behavior over time. But real-time fMRI neurofeedback takes a different approach by letting people see and learn to control their brain activity directly. This technique uses advanced imaging to give patients immediate feedback on their brain's function, potentially allowing them to self-regulate emotional responses. Researchers are excited because this method could offer faster relief and empower individuals with a hands-on tool to manage their symptoms.
What evidence suggests that real-time fMRI neurofeedback is effective for depression?
Research has shown that real-time fMRI neurofeedback might help with depression. In this trial, participants will join either an active neurofeedback group or a sham neurofeedback group. One study found that people with mild to moderate depression learned to control certain brain areas, potentially improving their mood. Another study discovered that this method led to behavioral improvements in up to 100% of individuals with major depressive disorder. This technique changes brain function and connectivity, which might help reduce depression symptoms. Early results suggest it could be a promising option for those who haven't succeeded with other treatments.15678
Who Is on the Research Team?
Yvette Sheline, M.D.
Principal Investigator
Center for Neuromodulation in Depression and Stress, University of Pennsylvania
Are You a Good Fit for This Trial?
This trial is for individuals with Major Depressive Disorder (MDD) or depression. Specific eligibility criteria are not provided, but typically participants must meet diagnostic criteria for MDD and may need to pass certain psychological assessments.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo three training sessions of real-time fMRI neurofeedback or sham feedback, each session lasting 32 minutes
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Real Time fMRI Neurofeedback
Trial Overview
The study is testing a new therapy that uses real-time fMRI neurofeedback to reduce negative attention bias in people with depression. It compares an active treatment against a sham (placebo-like) control to see if it can lessen the severity of depressive symptoms.
How Is the Trial Designed?
R33 Phase: Three training sessions. Each training session contains 32 minutes of active neurofeedback runs.
R33 Phase: Three training sessions. Each training session contains 32 minutes of sham (placebo) neurofeedback runs.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Pennsylvania
Lead Sponsor
Citations
Effectiveness of fMRI-based Neurofeedback Therapy on ...
This systematic review explores the efficacy of fMRI-based neurofeedback as an alternative treatment for individuals with depression who do not respond well ...
fMRI neurofeedback for the modulation of the neural ...
fMRI neurofeedback shows promise as a modulatory technique for depression, with the potential to induce significant changes in neural activity and connectivity ...
Targeting the affective brain—a randomized controlled trial ...
In one pilot study, we demonstrated that patients suffering from mild to moderate depression learnt to upregulate brain areas using real-time ...
The Clinical Impact of Real-Time fMRI Neurofeedback on ...
Concerning clinical subsamples, rt-fMRI-NFB-related behavioural improvement was observed in up to 100 percent of major depressive disorder (MDD) and post- ...
5.
bmcpsychiatry.biomedcentral.com
bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-023-05223-8Mindfulness-based real-time fMRI neurofeedback
This study aims to establish mindfulness-based real-time fMRI neurofeedback (mbNF) as a non-invasive approach to downregulate the default mode network (DMN)
NCT05640089 | FMRI-neurofeedback in Depression
Previous studies with fMRI-neurofeedback in depression have demonstrated a good safety profile and considerable symptom reduction. The goal of this clinical ...
Functional brain network dynamics of brooding in depression
In real-time fMRI neurofeedback, individuals receive live sensory (e.g., visual) feedback on their own brain activity during MRI scanning, with ...
Whole-brain mechanism of neurofeedback therapy
This study aimed to delineate the whole-brain mechanisms underpinning the effects of rtfMRI-NF on repetitive negative thinking in depression.
Other People Viewed
By Subject
By Trial
Related Searches
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.