31 Participants Needed

MBCT for Depression in Breast Cancer Survivors

JH
Overseen ByJacob Hill, ND
Age: 65+
Sex: Female
Trial Phase: Academic
Sponsor: Case Comprehensive Cancer Center
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

Do I need to stop my current medications to join the trial?

The trial does not specify if you need to stop taking your current medications, but it does require that there are no changes in antidepressant medication within 6 weeks before starting the trial.

What data supports the effectiveness of the treatment MBCT for Depression in Breast Cancer Survivors?

Research shows that Mindfulness-Based Cognitive Therapy (MBCT) is effective in reducing relapse rates in people with major depression, suggesting it could help breast cancer survivors with depression by teaching them mindfulness and cognitive-behavioral skills to manage their symptoms.12345

Is Mindfulness-Based Cognitive Therapy (MBCT) safe for humans?

Research on Mindfulness-Based Cognitive Therapy (MBCT) for various mental disorders, including depression, suggests it is generally safe for humans, with no significant safety concerns reported in the studies.23456

How is MBCT different from other treatments for depression in breast cancer survivors?

MBCT (Mindfulness-Based Cognitive Therapy) is unique because it combines mindfulness meditation with cognitive-behavioral techniques to help prevent depression relapse, focusing on teaching patients to stay well in the long-term.12347

What is the purpose of this trial?

The purpose of this research study is to develop and test an intervention designed to improve mood and reduce symptoms of depression.

Research Team

JH

Jacob Hill, ND

Principal Investigator

Cleveland Clinic Department of Wellness and Preventive Medicine, Cleveland Clinic, Case Comprehensive Cancer Center

Eligibility Criteria

This trial is for African American/Black women over 65 with mild to moderate depression and a history of Stage I, II or III breast cancer. They must speak English, have completed cancer treatment at least 3 months ago (except endocrine therapy), and be willing to consent to audio and video recording. Excluded are those with severe depression, recent changes in antidepressants, certain psychiatric conditions, daily meditation practice, or prior mindfulness training.

Inclusion Criteria

I am 65 years old or older.
African American/Black
Fluency in English
See 6 more

Exclusion Criteria

I have participated in mindfulness or stress reduction therapies before.
I meditate every day.
I have been diagnosed with severe depression.
See 2 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive the MBCT-Brief intervention, which includes 8 weekly 1-hour group sessions delivered via telephone or video teleconferencing

8 weeks
8 visits (virtual)

Follow-up

Participants are monitored for changes in quality of life, depressive symptoms, fear of recurrence, and trait mindfulness

4 weeks

Treatment Details

Interventions

  • MBCT
Trial Overview The study is testing an abbreviated form of Mindfulness-Based Cognitive Therapy (MBCT) designed to improve mood and reduce symptoms of depression in older African American/Black breast cancer survivors.
Participant Groups
1Treatment groups
Experimental Treatment
Group I: Mindfulness-Based Cognitive TherapyExperimental Treatment1 Intervention
MBCT-Brief includes 8 weekly 1-hour group sessions delivered either via telephone or video teleconferencing. The decision to deliver the intervention either via phone or teleconferencing will be made based on participant preference obtained during the formative focus groups. Telephone delivery of MBCT-Brief only requires a landline, while teleconferencing requires either a smartphone, tablet, or computer with audio and video functionality. During the MBCT-Brief intervention the instructor will lead in-session practice of medication and cognitive therapy exercises, guided inquiry, and assign and review at-home practice exercises. All sessions will be audio-recorded. Participants will be encouraged to practice daily meditation in between group sessions for 20 minutes, 6 days per week. Participants will complete practice logs to document daily meditation practice.

Find a Clinic Near You

Who Is Running the Clinical Trial?

Case Comprehensive Cancer Center

Lead Sponsor

Trials
472
Recruited
33,400+

Findings from Research

Mindfulness-based cognitive therapy (MBCT) is designed specifically for individuals at risk of depressive relapse, helping them learn strategies to maintain long-term mental wellness.
The article reviews existing research on the effectiveness of MBCT, highlighting its potential as a valuable psychological intervention for preventing future episodes of depression.
Mindfulness-based cognitive therapy: a promising new approach to preventing depressive relapse.Williams, JM., Kuyken, W.[2022]
Mindfulness-based cognitive therapy (MBCT) significantly reduces the risk of relapse or recurrence of major depressive disorder (MDD) by 34%, based on a meta-analysis of six randomized controlled trials involving 593 participants.
For patients with three or more previous episodes of MDD, MBCT offers a 43% reduction in relapse risk and is at least as effective as maintenance antidepressant medication, highlighting its potential as a valuable treatment option.
The effect of mindfulness-based cognitive therapy for prevention of relapse in recurrent major depressive disorder: a systematic review and meta-analysis.Piet, J., Hougaard, E.[2022]
Mindfulness-based cognitive therapy (MBCT) is highly valued by participants, with many describing it as 'life changing,' but about one-third of graduates still experience depression relapse within a year after completing the course.
Participants expressed a strong desire for additional support after MBCT, suggesting that a maintenance program could help them sustain mindfulness practices and reduce the risk of relapse.
Preventing Depression Relapse: A Qualitative Study on the Need for Additional Structured Support Following Mindfulness-Based Cognitive Therapy.Siwik, CJ., Adler, SR., Moran, PJ., et al.[2023]

References

Mindfulness-based cognitive therapy: a promising new approach to preventing depressive relapse. [2022]
The effect of mindfulness-based cognitive therapy for prevention of relapse in recurrent major depressive disorder: a systematic review and meta-analysis. [2022]
Preventing Depression Relapse: A Qualitative Study on the Need for Additional Structured Support Following Mindfulness-Based Cognitive Therapy. [2023]
Mindfulness-based cognitive therapy for residual depressive symptoms and relapse prophylaxis. [2019]
A systematic review and meta-ethnographic synthesis of Mindfulness-based Cognitive Therapy for people with major depression. [2023]
Effects of mindfulness-based cognitive therapy on mental disorders: a systematic review and meta-analysis of randomised controlled trials. [2020]
[Mindfulness-based cognitive therapy is efficient in the treatment of recurrent depression]. [2018]
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