← Back to Search

Antidepressants for Gum Disease in Patients With Depression

N/A
Waitlist Available
Research Sponsored by University of Alabama at Birmingham
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
At least 18 years old
Having moderate to severe periodontal disease according to AAP definition (teeth ≥5 mm PD and ≥3 mm CAL)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to 1 week
Awards & highlights

Study Summary

This trial will test whether antidepressants can help to treat gum disease by reducing inflammation.

Who is the study for?
This trial is for adults who are patients at the UAB Dental School with moderate to severe gum disease, as defined by specific dental measurements. It's open to those on antidepressants and those not suffering from depression but excludes non-English speakers, smokers, immunocompromised individuals, and anyone taking certain anti-inflammatory drugs or medications that could affect gum health.Check my eligibility
What is being tested?
The study is testing if antidepressants can lessen gum inflammation in people with periodontal disease. Participants will undergo standard periodontal surgery while their inflammatory markers are monitored to see if there's a difference between those with and without depression.See study design
What are the potential side effects?
While the document doesn't list specific side effects of the intervention (periodontal surgery), common ones may include swelling, bleeding, pain at the site of surgery, infection risk, and temporary discomfort during eating or brushing.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am 18 years old or older.
Select...
I have severe gum disease with deep pockets and gum recession.
Select...
I have at least 18 teeth, not counting wisdom teeth.
Select...
I am scheduled for a dental surgery soon.
Select...
I have chronic gum disease and do not suffer from depression.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to 1 week
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to 1 week for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Gingival crevicular fluid (GCF)
Secondary outcome measures
Plaque
Other outcome measures
Blood Serum
Patient Health Questionnaire 8 (PHQ8)
Soft tissue

Trial Design

3Treatment groups
Active Control
Group I: Chronic Periodontitis and Depression MedicationsActive Control1 Intervention
Patients with clinically diagnosed depression taking (SSRIs, NDRIs, SNRIs, tricyclic antidepressants) and with chronic periodontitis
Group II: Chronic PeriodontitisActive Control1 Intervention
Patients without depression, not taking any antidepressants and with chronic periodontitis
Group III: Chronic Periodontitis without Depression MedicationsActive Control1 Intervention
Patients with clinically diagnosed depression not taking any antidepressants (SSRIs NDRIs, SNRIs and Tricyclic antidepressants) and with chronic periodontitis

Find a Location

Who is running the clinical trial?

University of Alabama at BirminghamLead Sponsor
1,587 Previous Clinical Trials
2,280,180 Total Patients Enrolled
23 Trials studying Depression
2,537 Patients Enrolled for Depression

Media Library

Periodontal Surgery Clinical Trial Eligibility Overview. Trial Name: NCT03553095 — N/A
Depression Research Study Groups: Chronic Periodontitis and Depression Medications, Chronic Periodontitis, Chronic Periodontitis without Depression Medications
Depression Clinical Trial 2023: Periodontal Surgery Highlights & Side Effects. Trial Name: NCT03553095 — N/A
Periodontal Surgery 2023 Treatment Timeline for Medical Study. Trial Name: NCT03553095 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What criteria must be met in order to participate in this clinical research?

"To partake in the research, participants must suffer from depression and be within a certain age range (18 - 99). Currently, 92 people have been accepted."

Answered by AI

Is this trial still accepting new participants?

"The information present on clinicaltrials.gov indicates this trial is no longer actively seeking applicants. Initially posted in July of 2018, the details surrounding the study were modified for a final time on March 9th 2022. Although recruitment has ceased at this juncture, 1376 other studies are presently recruiting patients."

Answered by AI

Do elderly individuals over 85 qualify for enrollment in this medical research?

"To take part in this study, participants must be aged 18 or above and not surpass the age of 99."

Answered by AI

Who else is applying?

What state do they live in?
Alabama
How old are they?
18 - 65
What site did they apply to?
Unversity of Alabama at Birmingham, School of Dentistry
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
clinicaltrials.govStudy
Comparing Inflammatory Markers in Patients With and Without Depression With Chronic Periodontitis
Maninder Kaur 2018. "Comparing Inflammatory Markers in Patients With and Without Depression With Chronic Periodontitis". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03553095.
All > Depression > Treatment Resistant Depression
~14 spots leftby Apr 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top