Chronic Periodontitis and Depression Medications for Depression

Unversity of Alabama at Birmingham, School of Dentistry, Birmingham, AL
Targeting 2 different conditionsPeriodontal SurgeryN/AWaitlist AvailableResearch Sponsored by University of Alabama at Birmingham

Study Summary

This trial will test whether antidepressants can help to treat gum disease by reducing inflammation.

Eligible Conditions
  • Depression
  • Gum Disease

Eligibility Criteria

Inclusion Criteria

You will be eligible if you check “Yes” for the criteria below
You are currently taking medication for depression and have a long-term gum disease called chronic periodontitis.
You do not have depression along with chronic periodontitis (gum disease).


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to 1 week
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to 1 week for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Gingival crevicular fluid (GCF)
Secondary outcome measures
Other outcome measures
Blood Serum
Patient Health Questionnaire 8 (PHQ8)
Soft tissue

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups
Active Control
Group I: Chronic Periodontitis and Depression MedicationsActive Control1 Intervention
Patients with clinically diagnosed depression taking (SSRIs, NDRIs, SNRIs, tricyclic antidepressants) and with chronic periodontitis
Group II: Chronic PeriodontitisActive Control1 Intervention
Patients without depression, not taking any antidepressants and with chronic periodontitis
Group III: Chronic Periodontitis without Depression MedicationsActive Control1 Intervention
Patients with clinically diagnosed depression not taking any antidepressants (SSRIs NDRIs, SNRIs and Tricyclic antidepressants) and with chronic periodontitis

Find a site

Who is running the clinical trial?

University of Alabama at BirminghamLead Sponsor
1,509 Previous Clinical Trials
2,256,879 Total Patients Enrolled
21 Trials studying Depression
2,533 Patients Enrolled for Depression

Media Library

Periodontal Surgery Clinical Trial Eligibility Overview. Trial Name: NCT03553095 — N/A
Depression Research Study Groups: Chronic Periodontitis and Depression Medications, Chronic Periodontitis, Chronic Periodontitis without Depression Medications
Depression Clinical Trial 2023: Periodontal Surgery Highlights & Side Effects. Trial Name: NCT03553095 — N/A
Periodontal Surgery 2023 Treatment Timeline for Medical Study. Trial Name: NCT03553095 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What criteria must be met in order to participate in this clinical research?

"To partake in the research, participants must suffer from depression and be within a certain age range (18 - 99). Currently, 92 people have been accepted."

Answered by AI

Is this trial still accepting new participants?

"The information present on indicates this trial is no longer actively seeking applicants. Initially posted in July of 2018, the details surrounding the study were modified for a final time on March 9th 2022. Although recruitment has ceased at this juncture, 1376 other studies are presently recruiting patients."

Answered by AI

Do elderly individuals over 85 qualify for enrollment in this medical research?

"To take part in this study, participants must be aged 18 or above and not surpass the age of 99."

Answered by AI

Who else is applying?

What state do they live in?
How old are they?
18 - 65
What site did they apply to?
Unversity of Alabama at Birmingham, School of Dentistry
What portion of applicants met pre-screening criteria?
Met criteria
~15 spots leftby Oct 2024