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Neuromodulation

rTMS for Adolescent Depression

N/A

Recruiting

Research Sponsored by Sunnybrook Health Sciences Centre

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be younger than 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 2 years

Awards & highlights

Study Summary

This trial studies if a brain stimulation therapy can help depressed teens by changing how they process emotions.

Who is the study for?

This trial is for boys and girls aged 14-21 with major depression, as defined by the DSM-5. They must have a significant level of depression despite having tried at least one antidepressant treatment, be on a stable medication regimen for 4 weeks prior to the study without changes during it, and be able to follow all study procedures.Check my eligibility

What is being tested?

The study tests how rTMS (repetitive Transcranial Magnetic Stimulation), a non-invasive brain stimulation technique, affects emotional processing in depressed adolescents. It starts with one session followed by an open-label phase of active rTMS treatments over four weeks.See study design

What are the potential side effects?

rTMS may cause discomfort at the site of stimulation, headache, lightheadedness or seizures in very rare cases. Most side effects are mild and temporary.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 2 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~2 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Recruitment rates

Secondary outcome measures

estimating the magnitude of difference detectable in cortico-limbic activity between groups

Trial Design

2Treatment groups

Active Control

Placebo Group

Group I: Active StimulationActive Control1 Intervention

15 Depressed adolescents will undergo emotional processing tasks (within and outside the fMRI scanner) after one session of active rTMS

Group II: Sham StimulationPlacebo Group1 Intervention

15 Depressed adolescents will undergo emotional processing tasks (within and outside the fMRI scanner) after one session of sham rTMS

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Sunnybrook Health Sciences CentreLead Sponsor

656 Previous Clinical Trials

1,551,278 Total Patients Enrolled

Media Library

rTMS (Neuromodulation) Clinical Trial Eligibility Overview. Trial Name: NCT05832294 — N/A

Recruitment Research Study Groups: Active Stimulation, Sham Stimulation

Recruitment Clinical Trial 2023: rTMS Highlights & Side Effects. Trial Name: NCT05832294 — N/A

rTMS (Neuromodulation) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05832294 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the eligibility criteria for participants in this clinical trial?

"This trial is seeking 30 participants aged between 14 and 21. Any persons that meet the age criteria are encouraged to apply for recruitment."

Answered by AI

What is the greatest number of individuals currently involved in this clinical trial?

"Affirmative. The details published on clinicaltrials.gov suggest that this medical trial, which was first posted on April 20th of 2023, is actively recruiting volunteers to participate in the study. 30 persons are required at a single location for data collection purposes."

Answered by AI

Does this clinical research include participants of at least twenty years of age?

"This trial is for patients aged 14 to 21, with 193 trials targeting minors and 882 reserved for those above 65."

Answered by AI

Are there still open positions for participants in this investigation?

"Affirmative, the information hosted on clinicaltrials.gov demonstrates that this medical trial is actively seeking out participants. It was initially posted April 20th 2023 and recently updated April 14th of the same year. 30 test subjects are required across a single site."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Finding a Biomarker for Acute Neuromodulation Effects in Adolescent Depression

Dr. Peter Giacobbe 2023. "Finding a Biomarker for Acute Neuromodulation Effects in Adolescent Depression". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05832294.