← Back to Search

Early Mobility Intervention for Critically Ill Children (PICU Up! Trial)

N/A

Waitlist Available

Led By Sapna R Kudchadkar, MD, PhD

Research Sponsored by Johns Hopkins University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be younger than 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 28 days

Awards & highlights

PICU Up! Trial Summary

This trial will test the feasibility of a new program to help critically ill children recover more quickly by increasing their mobility while they are in the PICU.

Who is the study for?

This trial is for critically ill children in PICUs that haven't started a mobility program. It's open to all patients admitted, but only those staying 3 days or more are included in the data analysis. Children with an active do-not-resuscitate (DNR) order are excluded.Check my eligibility

What is being tested?

'PICU Up!' is being tested; it's a program combining sleep promotion, delirium prevention, and sedation optimization to encourage early mobilization of young patients in the PICU to improve their recovery and reduce ICU-acquired issues.See study design

What are the potential side effects?

Since 'PICU Up!' involves non-pharmaceutical interventions like movement and therapy activities rather than drugs, side effects aren't typical as with medication but may include fatigue or discomfort during physical activity.

PICU Up! Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 28 days

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~28 days

This trial's timeline: 3 weeks for screening, Varies for treatment, and 28 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Duration of mechanical ventilation (days)

Secondary outcome measures

Cumulative exposure to benzodiazepines (mg/kg) through PICU Day 28

Cumulative exposure to opioids (mg/kg) through PICU Day 28

Hospital length of stay (days)

+6 more

PICU Up! Trial Design

1Treatment groups

Experimental Treatment

Group I: PICU Up! pre- and post-implementationExperimental Treatment1 Intervention

Each unit will begin in the baseline, usual care phase and then be randomized to implement the PICU Up! program during a set time period, followed by the post-implementation phase.

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Johns Hopkins UniversityLead Sponsor

2,262 Previous Clinical Trials

14,820,664 Total Patients Enrolled

13 Trials studying Critical Illness

204,091 Patients Enrolled for Critical Illness

Donaghue Medical Research FoundationOTHER

23 Previous Clinical Trials

575,967 Total Patients Enrolled

1 Trials studying Critical Illness

3,500 Patients Enrolled for Critical Illness

Sapna R Kudchadkar, MD, PhDPrincipal InvestigatorJohns Hopkins University

1 Previous Clinical Trials

72 Total Patients Enrolled

Media Library

PICU Up! Clinical Trial Eligibility Overview. Trial Name: NCT03860168 — N/A

Critical Illness Research Study Groups: PICU Up! pre- and post-implementation

Critical Illness Clinical Trial 2023: PICU Up! Highlights & Side Effects. Trial Name: NCT03860168 — N/A

PICU Up! 2023 Treatment Timeline for Medical Study. Trial Name: NCT03860168 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are persons over forty eligible to enroll in this medical experiment?

"This trial is open to individuals aged 0-24. There are 20 studies specifically targeting minors and 151 for elderly persons over 65 years old."

Answered by AI

Could you provide details about who is eligible to take part in this research?

"This clinical trial seeks 2500 youth aged 0 to 24 with serious medical conditions. The requisite criteria for eligibility include admission in a dedicated PICU, 3 days or more of stay duration and no prior usage of mobility protocols until the randomized time of unit implementation."

Answered by AI

Has admissions for this trial been shut off or is it still taking on new participants?

"Accurate. According to clinicaltrials.gov, this medical investigation is not actively recruiting participants at the moment; it was posted on April 1st 2019 and last updated July 6th 2022. However, there are 168 other trials currently enrolling patients right now in lieu of this study's current non-participation status."

Answered by AI

Recent research and studies

Journal of Intensive Care MedicineJournal

Normal Baseline Function Is Associated with Delayed Rehabilitation in Critically Ill Children

Miura, Shinya, Beth Wieczorek, Hallie Lenker, and Sapna R. Kudchadkar. 2018. “Normal Baseline Function Is Associated with Delayed Rehabilitation in Critically Ill Children”. Journal of Intensive Care Medicine. SAGE Publications. doi:10.1177/0885066618754507.

Pediatric Critical Care MedicineJournal

PICU Up!

Wieczorek, Beth, Judith Ascenzi, Yun Kim, Hallie Lenker, Caroline Potter, Nehal J. Shata, Lauren Mitchell, et al.. 2016. “PICU Up!”. Pediatric Critical Care Medicine. Ovid Technologies (Wolters Kluwer Health). doi:10.1097/pcc.0000000000000983.

Critical Care MedicineJournal

Caring for Critically Ill Patients with the ABCDEF Bundle

Pun, Brenda T., Michele C. Balas, Mary Ann Barnes-Daly, Jennifer L. Thompson, J. Matthew Aldrich, Juliana Barr, Diane Byrum, et al.. 2019. “Caring for Critically Ill Patients with the ABCDEF Bundle”. Critical Care Medicine. Ovid Technologies (Wolters Kluwer Health). doi:10.1097/ccm.0000000000003482.

clinicaltrials.govStudy