Flu Vaccine for Coronavirus Infection
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores the effectiveness of the flu vaccine in individuals who have had COVID-19. Researchers aim to determine if previous COVID-19 infections, along with conditions like obesity, type 2 diabetes, or chronic fatigue, impact flu shot immunity over time. The study includes both individuals who have had COVID-19 and those who have not, providing a clearer picture of immunity differences. Suitable candidates for this trial include those who had COVID-19 at least two months ago and may have additional conditions like long-term COVID symptoms. Participants should not have received a flu vaccine in the last four months. As a Phase 2 trial, this study focuses on measuring the flu vaccine's effectiveness in an initial, smaller group, offering valuable insights into immunity.
Do I need to stop my current medications to join the trial?
The trial does not specify if you need to stop your current medications, but if you are taking immunomodulatory medications (drugs that affect the immune system), you may not be eligible to participate.
What is the safety track record for the flu shot?
Research has shown that the flu shot is generally safe for most people, including both adults and children. Many who receive the flu vaccine experience no side effects. When side effects occur, they are usually mild and resolve on their own. Common side effects include pain or redness at the injection site or occasionally a mild fever. Serious side effects are rare.
One study found that only a small number of people experience moderate to severe fever after receiving the flu vaccine. Specifically, 1.1% of those who received a high-dose flu shot reported this type of fever, compared to 0.3% of those who received a standard dose. Overall, the benefits of flu vaccination outweigh the risks, and the vaccine undergoes careful monitoring to ensure safety.12345Why are researchers excited about this trial?
Researchers are excited about this trial because it aims to uncover how COVID-19 affects immunity to the flu vaccine. Unlike typical flu vaccine studies that focus only on healthy individuals, this trial includes participants who have had COVID-19, providing insights into any potential differences in vaccine response. Understanding these differences could lead to improved vaccination strategies for people recovering from COVID-19, ultimately enhancing public health outcomes during flu season.
What evidence suggests that the flu shot is effective for immunity in patients who have had COVID-19?
Research has shown that flu vaccines are usually effective in preventing the flu. Studies indicate that getting a flu shot can lower the chance of contracting the flu by 40% to 60% during seasons when the vaccine matches the flu viruses well. Additionally, some research suggests that a flu vaccine might also reduce the risk of catching COVID-19 and needing hospitalization, offering an extra benefit for those who have had COVID-19. Overall, the flu shot is known to be safe and effective in lowering the risk of flu-related illness.
In this trial, participants will be divided into two groups: one group will receive the flu shot, while the other will serve as a control. This design will help evaluate the potential benefits of the flu shot in the context of COVID-19.678910Who Is on the Research Team?
Sayantani Sindher, MD
Principal Investigator
Stanford University
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Vaccination
Participants receive the flu vaccine to measure immunity over time
Follow-up
Participants are monitored for immunity response to the flu vaccine
What Are the Treatments Tested in This Trial?
Interventions
- Flu shot
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Find a Clinic Near You
Who Is Running the Clinical Trial?
Stanford University
Lead Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Collaborator
Citations
Updated Evidence for Covid-19, RSV, and Influenza ...
We reported outcomes for four domains: epidemiology, vaccine efficacy or effectiveness, safety, and coadministration. Epidemiologic data were ...
CDC Seasonal Flu Vaccine Effectiveness Studies
CDC conducts studies each flu season to help determine how well flu vaccines are working. These vaccine effectiveness (VE) studies help regularly assess the ...
Rationalizing recommendations for influenza and COVID ...
Here, we compare the effectiveness and safety of COVID-19 and influenza vaccines, as well as their effects on disease course and transmission, ...
The Association Between Previous Influenza Vaccination and ...
This meta-analysis showed that influenza vaccination was associated with reduced risk of COVID-19 infection (RR=0.83, 95% CI=0.76, 0.90) and hospitalization.
Study suggest dual COVID-19/flu shot is more effective ...
A previous Phase 1/2 study in 1,206 adults found that the vaccine was well-tolerated, had a good safety profile, and triggered immune responses ...
Influenza (Flu) Vaccine Safety
Many people who get an annual flu vaccine report no side effects at all. Most side effects reported after flu vaccination are mild and disappear ...
Influenza vaccines: Evaluation of the safety profile - PMC
Most influenza vaccines are safe in adults and children. However, they can sometimes cause AEs. According to the age-group, AEs may include fever, vomiting, ...
Safety of Influenza Vaccines
Only 1.1% of Fluzone High-Dose recipients reported moderate to severe fever, but this was significantly higher than the 0.3% of Fluzone recipients who reported ...
Flu Vaccine Safety
Are Flu Vaccines Safe? · The benefits of immunization outweigh the risks. · All vaccines are held to the highest standard of safety and are continually monitored.
Flu vaccine
Flu vaccines have a very good safety record. The most reported side effects of flu vaccines are: pain, swelling, bruising, hardness, or redness ...
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.