Medial Prefrontal Cortex (MPFC) for Obsessive-Compulsive Disorder

Stanford University, Stanford, CA
Obsessive-Compulsive DisorderRepetitive Transcranial Magnetic Stimulation - Device
Eligibility
18 - 80
All Sexes
What conditions do you have?
Select

Study Summary

This trial will study how brain activity affects OCD, and test new treatments to see if they help.

Eligible Conditions
  • Obsessive-Compulsive Disorder

Treatment Effectiveness

Phase-Based Effectiveness

1 of 3
N/A

Study Objectives

1 Primary · 1 Secondary · Reporting Duration: pre-treatment up to 1-month post-treatment

pre-treatment to 1-week post-treatment
OCD symptoms
pre-treatment up to 1-month post-treatment
resting-state functional connectivity (rsFC) of frontostriatal networks

Trial Safety

Side Effects for

rTMS With Sensorimotor Retraining, Then rTMS With CTL
40%Decreased balance
20%Abnormal Sleep Pattern
20%Mood change
This histogram enumerates side effects from a completed 2015 Phase 1 & 2 trial (NCT01738581) in the rTMS With Sensorimotor Retraining, Then rTMS With CTL ARM group. Side effects include: Decreased balance with 40%, Abnormal Sleep Pattern with 20%, Mood change with 20%.

Awards & Highlights

No Placebo Group
All patients enrolled in this trial will receive the new treatment.

Trial Design

2 Treatment Groups

Right Prefrontal Cortex (rPFC)
1 of 2
Medial Prefrontal Cortex (MPFC)
1 of 2

Active Control

Experimental Treatment

360 Total Participants · 2 Treatment Groups

Primary Treatment: Medial Prefrontal Cortex (MPFC) · No Placebo Group · N/A

Medial Prefrontal Cortex (MPFC)
Device
Experimental Group · 1 Intervention: Repetitive Transcranial Magnetic Stimulation · Intervention Types: Device
Right Prefrontal Cortex (rPFC)
Device
ActiveComparator Group · 1 Intervention: Repetitive Transcranial Magnetic Stimulation · Intervention Types: Device
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Repetitive Transcranial Magnetic Stimulation
2013
Completed Phase 3
~1130

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: pre-treatment up to 1-month post-treatment

Who is running the clinical trial?

Cornell UniversityOTHER
154 Previous Clinical Trials
14,088,471 Total Patients Enrolled
Foundation for OCD ResearchUNKNOWN
1 Previous Clinical Trials
120 Total Patients Enrolled
1 Trials studying Obsessive-Compulsive Disorder
120 Patients Enrolled for Obsessive-Compulsive Disorder
Stanford UniversityLead Sponsor
2,220 Previous Clinical Trials
34,902,244 Total Patients Enrolled
11 Trials studying Obsessive-Compulsive Disorder
840 Patients Enrolled for Obsessive-Compulsive Disorder
David Spiegel, MDStudy DirectorStanford University
8 Previous Clinical Trials
1,232 Total Patients Enrolled
Nolan Williams, MDPrincipal InvestigatorStanford University
16 Previous Clinical Trials
878 Total Patients Enrolled
1 Trials studying Obsessive-Compulsive Disorder
180 Patients Enrolled for Obsessive-Compulsive Disorder

Eligibility Criteria

Age 18 - 80 · All Participants · 10 Total Inclusion Criteria

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Frequently Asked Questions

Are there any vacancies available in this trial for individuals seeking treatment?

"Affirmative. According to clinicaltrials.gov, this research project is in full recruitment mode as of April 24th 2023. Initially posted on March 14th 2022, it aims to enrol 360 participants from two distinct medical centres." - Anonymous Online Contributor

Unverified Answer

Am I eligible to join this research endeavor?

"This clinical trial seeks to enrol 360 participants, who must be between 18 and 80 years old with a diagnosis of obsessive-compulsive disorder." - Anonymous Online Contributor

Unverified Answer

How many participants are part of this clinical experiment?

"Yes, the trial is currently open for enrollment. As per information on clinicaltrials.gov, this study was first uploaded on March 14th of 2022 and most recently updated April 24th 2023. The research team seeks 360 participants across two distinct locations." - Anonymous Online Contributor

Unverified Answer

Is this investigation open to those aged 55 and above?

"This trial only enrols patients aged 18 to 80. Those younger than 18 can join one of the 22 trials available, while those older than 65 are able to choose from 69 medical studies." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.