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Exercise for Mild Cognitive Impairment

N/A
Recruiting
Research Sponsored by McMaster University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1-7 days prior to intervention , 1-7 days post intervention
Awards & highlights

Study Summary

This trial studies how physical exercise can improve cognition in aging and people with Mild Cognitive Impairment (MCI). It could lead to new ways to improve thinking skills in older adults. #Ageing #Cognition #MCI #Exercise

Who is the study for?
This trial is for adults with mild cognitive impairment (MCI) or those experiencing normal aging who want to improve their cognition. Participants should be able to perform physical exercise and not have any conditions that would prevent them from receiving repetitive transcranial magnetic stimulation.Check my eligibility
What is being tested?
The study tests if self-determined intensity interval training, a form of exercise, can change synaptic plasticity in the brain. This could relate to improved thinking abilities in both healthy older adults and those with MCI.See study design
What are the potential side effects?
While specific side effects are not listed, typical risks may include muscle soreness or fatigue due to exercise. The research will monitor participants closely for any adverse reactions.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1-7 days prior to intervention , 1-7 days post intervention
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1-7 days prior to intervention , 1-7 days post intervention for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change from Baseline Synaptic Plasticity at 4 weeks
Secondary outcome measures
Change from Baseline Brain Derived Neurotropic Factor at 4 weeks
Change from Baseline Cognitive function at 4 weeks
Change from Baseline Osteocalcin at 4 weeks
+1 more

Trial Design

3Treatment groups
Active Control
Group I: Exercise Training in Individuals with Mild Cognitive ImpairmentActive Control1 Intervention
Individuals will participate in 3 sessions of Self Determined Intensity Interval training per week for 4 weeks, using a stationary bike at an intensity whereby their Ratings of Perceived exertion (RPE) is challenging. RPE will be measured using a Borg's 6-20 scale. (44). The cycling protocol will include a 3-minute warm-up, five, 1-minute cycling intervals, interspersed with 1.5 minutes of recovery. and a 2-minute cool-down. The RPE will be acquired by asking the participant to provide their rating at the end of the last interval.
Group II: Individuals with Mild Cognitive Impairment and No exerciseActive Control1 Intervention
Group B: Participants in this arm will not experience any intervention during a 4 week period of time.
Group III: Exercise Training in age and sex matched healthy controlsActive Control1 Intervention
Individuals will participate in 3 sessions of Self Determined Intensity Interval training per week for 4 weeks, using a stationary bike at an intensity whereby their Ratings of Perceived exertion (RPE) is challenging. RPE will be measured using a Borg's 6-20 scale. (44). The cycling protocol will include a 3-minute warm-up, five, 1-minute cycling intervals, interspersed with 1.5 minutes of recovery. and a 2-minute cool-down. The RPE will be acquired by asking the participant to provide their rating at the end of the last interval.

Find a Location

Who is running the clinical trial?

McMaster UniversityLead Sponsor
879 Previous Clinical Trials
2,596,940 Total Patients Enrolled
McMaster Institute for Research in AgingUNKNOWN
Canada Research ChairUNKNOWN

Media Library

Self-determined Intensity Interval Training Clinical Trial Eligibility Overview. Trial Name: NCT05663918 — N/A
Mild Cognitive Impairment Research Study Groups: Exercise Training in Individuals with Mild Cognitive Impairment, Individuals with Mild Cognitive Impairment and No exercise, Exercise Training in age and sex matched healthy controls
Mild Cognitive Impairment Clinical Trial 2023: Self-determined Intensity Interval Training Highlights & Side Effects. Trial Name: NCT05663918 — N/A
Self-determined Intensity Interval Training 2023 Treatment Timeline for Medical Study. Trial Name: NCT05663918 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this study open to elderly individuals over the age of 75?

"Eligibility for this clinical trial is determined by the patient's age, which must be between 50 and 70 years of age."

Answered by AI

Are there any eligibility criteria that would prevent me from participating in this trial?

"This trial is recruiting 36 individuals with mild cognitive impairment (MCI) who are aged between 50 and 70. To be eligible for assignment to either Group A or Group B, applicants must have a diagnosis of MCI that meets the study criteria."

Answered by AI

Are there any open slots for participation in this research project?

"This study, which was initially posted on January 1st 2023 and last modified in December 15th 2022, does not appear to be recruiting patients at this time. However, there are currently 576 different clinical trials actively welcoming participants across the world."

Answered by AI
~15 spots leftby Jan 2025