AP-Brain for Cognitive Functioning
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a new supplement, AP-Brain, to determine if it can improve attention and memory in healthy younger adults who often have trouble focusing. Participants will take varying doses of AP-Brain or a placebo to compare effects on cognitive function over about two months. The study seeks individuals aged 18-39 who frequently struggle with attention and can maintain a stable lifestyle throughout the trial. As an unphased trial, it offers participants the chance to contribute to groundbreaking research on cognitive enhancement.
Will I have to stop taking my current medications?
The trial requires participants to maintain their current lifestyle habits, including medications, as much as possible throughout the study. However, if you are taking medications that might impact the study's safety or efficacy, you may need to stop or adjust them. It's best to discuss your specific medications with the study team.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Studies have shown that hydrolyzed collagen, such as that used in AP-Brain, is generally safe and well-tolerated. A study on a similar product, CollaSel Pro®, found it safe for improving skin health, with no serious side effects reported. Research suggests that collagen peptides can positively impact brain structure and improve language skills, indicating safety for brain use. Although collagen supplements are not recommended during pregnancy or breastfeeding due to limited data, they have not shown major safety issues in other adults.12345
Why are researchers excited about this trial?
Unlike other treatments for cognitive functioning, which often focus on enhancing neurotransmitter activity or blood flow to the brain, AP-Brain is derived from hydrolyzed collagen. This makes it unique because it introduces a new active ingredient not typically used in this field. Researchers are excited about AP-Brain because it explores the potential benefits of collagen on brain health, offering a novel approach with different dosages: 1g, 3g, and 5g. This could pave the way for alternative or complementary options to existing cognitive enhancers.
What evidence suggests that AP-Brain could be an effective treatment for attention problems?
Research has shown that collagen supplements might improve brain health and thinking skills. Some studies found that daily collagen intake can alter the brain and enhance language skills. These findings suggest potential brain benefits from collagen. However, the benefits appear stronger with higher doses, around 10 to 20 grams, taken over an extended period. In this trial, participants will receive different dosages of AP-Brain—specifically 1g, 3g, or 5g—or a placebo. Although this trial uses different dosages, the potential for cognitive improvements remains promising.26789
Who Is on the Research Team?
David Crowley, MD
Principal Investigator
KGK Science Inc.
Are You a Good Fit for This Trial?
This trial is for healthy younger adults who feel they have attention issues. Participants will be asked to take a substance called AP-Brain at different doses or a placebo and complete memory tests.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive AP-Brain at varying dosages (1g, 3g, or 5g) or placebo and complete memory assessment questionnaires
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- AP-Brain
Trial Overview
The study is testing the safety and effectiveness of varying doses of AP-Brain (1g, 3g, or 5g) compared to a placebo in improving cognitive function over 56 days in participants with self-reported attention problems.
How Is the Trial Designed?
4
Treatment groups
Experimental Treatment
Placebo Group
AP-Brain (5 g) contains 5 g of hydrolyzed collagen in a capsule
AP-Brain (3 g) contains 3 g of hydrolyzed collagen in a capsule
AP-Brain (1g) contains 1 g of hydrolyzed collagen in a capsule
Placebo consists of Silicified Microcrystalline Cellulose, magnesium stearate, Hydroxypropyl cellulose, and titanium dioxide
Find a Clinic Near You
Who Is Running the Clinical Trial?
Rousselot BVBA
Lead Sponsor
KGK Science Inc.
Industry Sponsor
Najla Guthrie
KGK Science Inc.
Chief Executive Officer since 1997
Research career at the Centre for Human Nutrition, University of Western Ontario
Dr. Bibiane Zakaria
KGK Science Inc.
Chief Medical Officer since 2023
MD from an unspecified institution
Citations
Effects of Collagen Hydrolysates on Human Brain Structure ...
It is possible that the ingestion of CH may change brain structure and improve cognitive function, potentially helping patients to recover from brain damage. In ...
2.
researchgate.net
researchgate.net/publication/338141617_Effects_of_Collagen_Hydrolysates_on_Human_Brain_Structure_and_Cognitive_Function_A_Pilot_Clinical_Study(PDF) Effects of Collagen Hydrolysates on Human Brain ...
This study investigated the effects of collagen hydrolysates (CH) on language cognitive function and brain structure.
Collagen peptides supplementation improves function ...
These findings suggest 10 to 20 g/d of CP supplementation over 6 to 9 months may improve ADLs, pain, MCS, and PCS in middle-aged active adults.
Effects of Collagen Hydrolysates on Human Brain Structure ...
Daily ingestion of CH changed brain structure and improved language cognitive function. Keywords: cognitive health; collagen hydrolysate ...
5.
examine.com
examine.com/research-feed/study/dxqJN1/?srsltid=AfmBOoofQwhGyOwtp92rE4XJ1_DXxd9BpjtmH5OCFAaK2b_uTMqgZL3sCollagen supplementation for sleep among physically ...
In this randomized controlled trial in physically active men, supplementation with collagen did not reduce sleep latency or improve sleep efficiency.
A Clinical Trial to Investigate the Safety and Efficacy of AP ...
The goal of this clinical trial is to investigate the safety and efficacy of AP-Brain on cognitive function at varying dosages in healthy ...
The Efficacy and Safety of CollaSel Pro® Hydrolyzed ...
Accordingly, CollaSel Pro® hydrolyzed collagen peptide can be considered a well-tolerated, safe product that effectively improves dermal health ...
8.
news-medical.net
news-medical.net/health/Do-Collagen-Supplements-Work-Science-Backed-Benefits-for-Skin-Joints-and-Muscles.aspxDo Collagen Supplements Work? Science-Backed Benefits ...
Not recommended in pregnancy or breastfeeding due to insufficient safety data9. Limitations and controversies. Collagen supplements vary ...
Ingestion of a collagen peptide containing high concentrations ...
Furthermore, they have been confirmed to cause changes in the brain's structure and improve language cognitive function (Koizumi et al.2020).
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