Lymph Node Biology for Kidney Cancer
(LN-RCC Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to understand the behavior of certain immune cells (T cells) in lymph nodes of people with kidney cancer. Researchers will collect samples from tumors, nearby non-cancerous kidney tissue, blood, and lymph nodes to study these cells. The goal is to discover new ways to detect and treat kidney cancer. The trial seeks adults diagnosed with or suspected to have kidney cancer who are receiving care at Yale's cancer centers. As an unphased study, this trial offers a unique opportunity to contribute to groundbreaking research that could lead to new diagnostic and treatment methods for kidney cancer.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the study investigators for guidance.
Why are researchers excited about this trial?
Researchers are excited about this trial because it delves into the biological environment of kidney cancer by analyzing various specimens, including tumor samples, lymph nodes, and blood. Unlike traditional kidney cancer treatments that primarily focus on targeting and shrinking tumors directly, this approach aims to understand the tumor's interactions with its surroundings and the immune system. By examining both malignant and non-malignant tissues as well as immune responses, researchers hope to uncover new insights that could lead to more personalized and effective treatment strategies in the future.
Who Is on the Research Team?
David Braun, MD
Principal Investigator
Yale University
Are You a Good Fit for This Trial?
This trial is for individuals with kidney cancer, specifically Renal Cell Carcinoma. Participants will contribute samples like lymph nodes, non-cancerous kidney tissue, blood, and tumor tissue to help create a repository for ongoing and future research.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Specimen Collection
Collection and analysis of tissue specimens and blood samples at relevant treatment time points
Follow-up
Participants are monitored for safety and effectiveness after specimen collection
What Are the Treatments Tested in This Trial?
Interventions
- Adjacent non-malignant kidney for analysis
- Draining lymph node(s) for analysis
- Peripheral Blood Sample for Immune Analysis
- Regional non-draining lymph node(s) for analysis
- Tumor Sample for Analysis
Find a Clinic Near You
Who Is Running the Clinical Trial?
Yale University
Lead Sponsor