Magnetic Resonance Elastography for Liver Cancer
Trial Summary
Do I need to stop my current medications for this trial?
The trial protocol does not specify whether you need to stop taking your current medications.
What data supports the idea that Magnetic Resonance Elastography for Liver Cancer is an effective treatment?
The available research shows that Magnetic Resonance Elastography (MRE) is useful in predicting the early return of liver cancer after treatment by measuring liver stiffness. This can help doctors decide on the best treatment plan. Additionally, MRE can help evaluate how well patients with advanced liver cancer respond to immunotherapy, a type of treatment that uses the body's immune system to fight cancer. While MRE is not a treatment itself, it supports other treatments by providing important information about the liver's condition and the effectiveness of ongoing therapies.12345
What safety data exists for Magnetic Resonance Elastography (MRE) in liver cancer treatment?
The available research indicates that Magnetic Resonance Elastography (MRE) is a non-invasive and safe technique for assessing liver stiffness and fibrosis. It is described as having excellent reproducibility, repeatability, and interobserver agreement, making it a reliable method for liver evaluation. MRE is applicable to almost all patients and body types, and it is considered the most accurate non-invasive technique for detecting and staging liver fibrosis, with the potential to replace liver biopsy. No specific safety concerns are highlighted in the provided studies, suggesting that MRE is generally considered safe for use in liver cancer assessment.678910
Is Magnetic Resonance Elastography a promising treatment for liver cancer?
Yes, Magnetic Resonance Elastography (MRE) is a promising treatment for liver cancer. It is a non-invasive method that helps doctors measure how stiff the liver is, which can be important for detecting liver problems early. MRE can also help predict if liver cancer might come back after treatment, making it a valuable tool for managing liver health.1671112
What is the purpose of this trial?
This trial studies how well an investigational scan (magnetic resonance elastography \[MRE\]) works with standard imaging (magnetic resonance imaging \[MRI\]) in detecting response to treatment in patients with liver cancer that has spread to other places in the body. Diagnostic procedures, such as MRE with MRI, may make it easier for researchers to see if the treatment for liver cancer is working.
Research Team
Priya R. Bhosale
Principal Investigator
M.D. Anderson Cancer Center
Eligibility Criteria
This trial is for patients with advanced liver cancer that has spread, who have biopsy-proven hepatocellular carcinoma (HCC) and can provide tissue samples. Participants must not have any conditions that make MRI unsafe, like metal implants or fragments in the body, and cannot be pregnant. They must also be able to give informed consent.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Patients undergo standard of care MRI and MRE within 5 days of liver biopsy before receiving any medical treatment for HCC
Initial Treatment Assessment
MRE and MRI are performed to assess changes in liver tumor stiffness and necrosis after 6 weeks of treatment
Ongoing Monitoring
Patients undergo MRI and MRE every 12 weeks to monitor treatment response and tumor progression
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Investigational Scan
- Standard Imaging
Find a Clinic Near You
Who Is Running the Clinical Trial?
M.D. Anderson Cancer Center
Lead Sponsor
National Cancer Institute (NCI)
Collaborator