Negative Pressure Wound Therapy for Breast Reconstruction in Obese Patients
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial studies the safety and how well negative pressure wound therapy works in healing the abdominal incision in obese patients undergoing free flap breast reconstruction surgery. Using negative pressure wound therapy (NPWT) instead of standard dressing (bandages) may improve wound healing at the surgical site in the abdomen where tissue was collected for breast reconstruction surgery.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
Is negative pressure wound therapy (NPWT) safe for humans?
Negative pressure wound therapy (NPWT), also known as vacuum-assisted closure (VAC) or topical negative pressure (TNP) therapy, has been used safely in humans for over 50 years to promote healing in various types of wounds, including infected and chronic wounds. It has been shown to increase blood flow and reduce bacteria in wounds, which supports its safety profile.12345
How does negative pressure wound therapy differ from other treatments for breast reconstruction in obese patients?
Negative pressure wound therapy (NPWT) is unique because it uses a vacuum to apply negative pressure to the wound, which helps increase blood flow, reduce fluid buildup, and promote faster healing. This method can decrease complications and improve scar quality compared to standard treatments, especially in breast reconstruction surgeries.13467
What data supports the effectiveness of the treatment Negative Pressure Wound Therapy for breast reconstruction in obese patients?
Existing data suggests that Negative Pressure Wound Therapy (NPWT) can reduce complications and improve healing in breast surgery, such as decreasing seroma formation and overall complications after expander-based breast reconstruction. However, more large studies are needed to confirm its effectiveness specifically in breast surgery.13478
Who Is on the Research Team?
Edward I. Chang
Principal Investigator
M.D. Anderson Cancer Center
Are You a Good Fit for This Trial?
This trial is for obese patients with a BMI of 30 or higher who are undergoing free flap breast reconstruction surgery after breast cancer. They must be able to consent and not have allergies to topical adhesives. Pregnant individuals cannot participate.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Patients receive either standard dressing or negative pressure wound therapy (NPWT) after surgery for 7 days
Follow-up
Participants are monitored for wound healing complications and adverse events
What Are the Treatments Tested in This Trial?
Interventions
- Negative Pressure Wound Therapy
- Wound Care Management
Negative Pressure Wound Therapy is already approved in United States, European Union, Canada, Switzerland for the following indications:
- Acute wounds
- Chronic wounds
- Diabetic foot ulcers
- Skin grafts
- Surgical incisions
- Burns
- Acute wounds
- Chronic wounds
- Diabetic foot ulcers
- Skin grafts
- Surgical incisions
- Burns
- Acute wounds
- Chronic wounds
- Diabetic foot ulcers
- Skin grafts
- Surgical incisions
- Burns
- Acute wounds
- Chronic wounds
- Diabetic foot ulcers
- Skin grafts
- Surgical incisions
- Burns
Find a Clinic Near You
Who Is Running the Clinical Trial?
M.D. Anderson Cancer Center
Lead Sponsor
National Cancer Institute (NCI)
Collaborator