Rapid MRI for Traumatic Brain Injury

Recruiting at 1 trial location

Overseen By Chantel Debert, MD, MSc

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: D.J Cook

Disqualifiers: Brain surgery, Neurologic, Psychiatric, Substance use, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 2

300 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests a new method of using MRI scans to understand and predict the effects of traumatic brain injuries (TBIs). The goal is to develop a quick and easy MRI process that reveals damage not typically visible, which is linked to ongoing TBI symptoms. The trial consists of two parts: one involves MRIs and check-ups for individuals with recent TBIs, and the other involves focus groups to design helpful reports for patients and caregivers. The trial seeks participants recently diagnosed with a TBI who can undergo an MRI and attend follow-up appointments. It also seeks individuals with long-term TBI, their caregivers, TBI doctors, and professionals such as lawyers or insurance adjusters specializing in TBI cases. As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research that could enhance TBI diagnosis and care.

Why are researchers excited about this trial?

Researchers are excited about using rapid MRI for assessing functional abilities and predicting outcomes in traumatic brain injury (TBI) patients because it offers a non-invasive and faster way to evaluate brain function compared to traditional imaging techniques like CT scans. Unlike standard methods, which can be time-consuming and involve radiation exposure, rapid MRI provides detailed images without radiation, making it safer, especially for repeated use. Additionally, it has the potential to give quicker insights into brain injuries, which could lead to faster and more personalized treatment decisions.

What evidence suggests that this MRI technique is effective for assessing traumatic brain injury?

Research has shown that rapid MRI scans can be more effective than CT scans for diagnosing traumatic brain injuries (TBI). A review of studies found that MRI can detect injuries that CT scans might miss. Early results from other research suggest that rapid MRI excels at identifying mild brain injuries, especially in children. Timing is crucial: MRIs performed within 72 hours of the injury can provide valuable information about the severity and potential recovery from TBI. Overall, rapid MRI offers promising improvements in assessing brain injuries more effectively and quickly compared to traditional methods. ^{1 2 3 4 5}

Who Is on the Research Team?

Douglas J Cook, MD, PhD

Principal Investigator

Queen's University

Are You a Good Fit for This Trial?

Inclusion Criteria

I have had an MRI recently.

- Diagnosis of TBI

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Acute Assessment

Participants undergo novel MRI and functional assessments in the acute stages after injury

Up to 45 minutes for MRI

1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment, with a complete reassessment of function three months after injury

90 days

1 visit (in-person)

Report Development

Focus groups conducted to develop report content and format for different stakeholders

What Are the Treatments Tested in This Trial?

Who Is Running the Clinical Trial?

D.J Cook

Lead Sponsor

Trials

1

Recruited

300+

D.J Cook

Lead Sponsor

Trials

1

Recruited

300+

University of Calgary

Collaborator

Trials

827

Recruited

902,000+

Citations

1.

pmc.ncbi.nlm.nih.gov

pmc.ncbi.nlm.nih.gov/articles/PMC11579544/

Comparative Efficacy of MRI and CT in Traumatic Brain Injury

This systematic review evaluates the diagnostic capabilities of magnetic resonance imaging (MRI) compared to computed tomography (CT) in assessing TBI across ...

2.

clinicaltrials.gov

clinicaltrials.gov/study/NCT06454591

Study Details | NCT06454591 | Rapid MRI for Assessing ...

Our project aims to develop a rapidly acquired and communicated MRI assessment and report that incorporates functional and structural imaging to convey ...

3.

now.ohsu.edu

now.ohsu.edu/Post/new-mri-approach-effectively-diagnoses-mild-brain-injuries-children/a7b0a50f-fa58-4a84-b6c1-2c194a67d15f

New MRI approach effectively diagnoses mild brain ...

OHSU study is the first to use rapid MRI as a standard evaluation pathway for traumatic brain injury in children.

4.

thejns.org

thejns.org/pediatrics/view/journals/j-neurosurg-pediatr/28/3/article-p278.xml

Rapid-sequence MRI for evaluation of pediatric traumatic ...

This systematic review sought to examine studies of clinical RSMRI use for pediatric traumatic brain injury (TBI) and to evaluate various RSMRI protocols used.

5.

mdpi.com

mdpi.com/2077-0383/14/12/4078

Timing of Magnetic Resonance Imaging (MRI) in Moderate ...

Current evidence suggests that MRI performed within 72 h after injury in ICU-treated patients with moderate and severe TBI offers valuable prognostic insights.