Diffuse Optical Spectroscopy for Muscle Disorders and Bone Disease
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to uncover the genetic causes of muscle diseases that occur alongside bone diseases, which appear to run in families. Researchers will use Diffuse Optical Spectroscopy, a non-invasive imaging technique, to study muscle and bone health by measuring how light interacts with tissues. This study may suit individuals with both muscle and bone problems, especially if these issues are common in their family. As an unphased trial, it offers a unique opportunity to contribute to groundbreaking research that could lead to new insights and treatments for muscle and bone diseases.
Do I have to stop taking my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to ask the trial organizers for more details.
What prior data suggests that this device is safe for measuring tissue physiology?
Research has shown that Diffuse Optical Spectroscopy is generally safe and easy to handle. Studies have found that this method is non-invasive, meaning it doesn't involve surgery or entering the body. It uses light to measure blood and water levels in tissues.
In past studies, no serious side effects or harm were reported. The technique resembles using a flashlight to look inside. It doesn't involve radiation or anything harmful. So far, it appears to be a safe way to study muscle and bone conditions.12345Why are researchers excited about this trial?
Researchers are excited about using Diffuse Optical Spectroscopy (DOS) for conditions like familial myopathy and Paget disease of bone because it offers a non-invasive way to study muscle and bone activity. Unlike traditional imaging methods, DOS uses light to measure changes in tissue composition and blood flow, providing real-time insights without the need for radiation or contrast agents. This technique could lead to earlier detection and a better understanding of these conditions, potentially paving the way for more targeted and effective treatments in the future.
What evidence suggests that Diffuse Optical Spectroscopy is effective for measuring tissue physiology in muscle disease?
This trial will evaluate the use of Diffuse Optical Spectroscopy (DOS) for monitoring muscle health in participants with muscle weakness. Studies have shown that DOS can help by checking blood flow and oxygen levels in muscles. Research suggests that DOS is useful for testing strength and aiding muscle recovery. It measures the amounts of blood, water, and fats in muscles, providing insights into their function. This technology has effectively assessed muscle health and could be a promising tool for people with muscle weakness. It offers a non-invasive way to examine muscle and bone health, potentially benefiting those with inherited conditions.16789
Who Is on the Research Team?
Virginia Kimonis, MD
Principal Investigator
Beckman Laser Institute University of California Irvine
Bruce Tromberg, PhD
Principal Investigator
Beckman Laser Institute University of California Irvine
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Measurement
Diffuse Optical Spectroscopy measurements are taken to assess tissue physiology
Follow-up
Participants are monitored for any changes in tissue physiology and overall health
What Are the Treatments Tested in This Trial?
Interventions
- Diffuse Optical Spectroscopy
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Diffuse Optical Spectroscopy
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Irvine
Lead Sponsor
Beckman Laser Institute University of California Irvine
Collaborator
Citations
Hybrid diffuse optical techniques for continuous ...
This study adapted a hybrid near-infrared spectroscopy and diffuse correlation spectroscopy system with a gating algorithm to continuously quantify hemodynamic ...
2.
spiedigitallibrary.org
spiedigitallibrary.org/conference-proceedings-of-spie/8578/857803/Use-of-diffuse-optical-spectroscopy-to-monitor-muscle-and-brain/10.1117/12.2007459.pdfUse of Diffuse Optical Spectroscopy to Monitor Muscle and ...
These experiments demonstrate novel applications for diffuse optical spectroscopy in strength testing and targeted muscle rehabilitation.
Analysis of muscle tissue in vivo using fiber-optic ...
These findings support the utility of in vivo fiber-optic AF and DR spectroscopy for the assessment of muscle tissue.
4.
frontiersin.org
frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2021.800051/fullEvaluation of Local Skeletal Muscle Blood Flow in ...
These results suggest that MT could increase the local blood flow to the target skeletal muscle, with minimal effects on systemic circulatory function.
Use of Diffuse Optical Spectroscopy to Monitor Muscle and ...
Pre- and post-training data collection included an aerobic capacity test, MR imaging, strength testing, and vastus lateralis muscle biopsy.
Spectroscopy detects skeletal muscle microvascular ...
The objectives of this study were to determine whether early microvascular dysfunction (MVD) in skeletal muscle can be detected as dynamic changes in ...
In Vivo Fiber Optic Raman Spectroscopy of Muscle in ...
In this study, we have developed and tested an in vivo intramuscular fiber optic Raman technique in two mouse models of devastating human neuromuscular ...
Optical Spectroscopic Analysis of Muscle Spasticity for Low ...
Recent studies have suggested that a diffuse optical signal measured over the near-infrared spectral range provides sufficient information of hemoglobin ...
Diffuse Optical Spectroscopy Assessment of Resting ...
Near-infrared spectroscopy (NIRS) provides a low-cost, non-invasive means to assess localized, resting-state muscle oxygen metabolism during venous or arterial ...
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